基本信息
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职业迁徙
个人简介
Investigation of endothelial cell biology in health and disease is my field of interest. With a
background in cell and molecular biology, I am trying to understand molecular mechanisms
of endothelial-related complications in human, particularly when coagulation Factor VIII
(FVIII) is involved. FVIII is a key player in blood coagulation. High FVIII levels are
associated with an increased incidence of venous thrombosis and thromboembolism.
Conversely, reduced levels of FVIII are responsible for the most severe hereditary bleeding
disorder, Hemophilia A.
My Ph.D. thesis involved studying human endothelial cells from various anatomical
locations as the potential sites of FVIII production that was still plausible at that time;
despite our deep knowledge about the factor structure and function. The study demonstrated
endothelial cells from major organs including, heart, lung, kidney, skin and intestine are
capable of constitutive and regulated FVIII production. My post-doctoral project was
concentrated on the human liver as the main site of FVIII production to unravel the exact
FVIII producing cell type within this organ. In this study several methods were included for
deep characterization of isolated cells, such as FVIII functional assays and whole RNA
profiling using RNAseq.
研究兴趣
论文共 23 篇作者统计合作学者相似作者
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Journal of Cellular and Molecular Medicineno. 1 (2022): 30-35
Razie Rezaie,Zeinab Falakian,Saeideh Mazloomzadeh,Mohsen Ayati,Arman Morakabati, Mohammad Reza Teimouri Dastjerdan, Mohammad Zare,Minoosh Moghimi,Tina Shahani,Alireza Biglari
JOURNAL OF CLINICAL LABORATORY ANALYSISno. 2.0 (2019): e22663-e22663
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