基本信息
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职业迁徙
个人简介
For many years, I have been interested in lung development and disease, especially research focused on defining the molecular machinery that maintains the integrity and role of the epithelial barrier in the lung.
The primary research my colleagues and I concentrate on is identifying the molecular pathways that connect mutations in the SFTPC gene (encoding surfactant protein C) to the occurrence of interstitial lung disease (ILD) among both adults and children.
My laboratory has achieved multiple notable discoveries. We have a long history for discovery dating back to our first finding that overexpression of a disease-associated SFTPC allele in terms of the endogenous WT allele gave rise to type II epithelial cell (AT2) injury/fatality in transgenic mice, which was associated with endoplasmic reticulum (ER) stress in both mouse and human AT2 models.
We subsequently identified ER chaperones that are part of the folding/maturation of the SP-C proprotein. We established that ERdj4 was a vital element of the quality control mechanisms needed for recognition and quick degradation of the mutant SP-C proprotein.
Interests
Lung development; chaperone biology and diseases of protein misfolding; pulmonary fibrosis; asthma; respiratory distress syndrome; acute and chronic lung disease
Research Areas
Pulmonary Biology, Fibrosis
研究兴趣
论文共 249 篇作者统计合作学者相似作者
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期刊级别
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American journal of biological anthropology (2023)
Natureno. 7972 (2023): E11-E11
AMERICAN JOURNAL OF BIOLOGICAL ANTHROPOLOGY (2023): 3-3
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American journal of biological anthropologyno. 2 (2023): 182-194
AMERICAN JOURNAL OF BIOLOGICAL ANTHROPOLOGY (2023): 28-29
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AMERICAN JOURNAL OF BIOLOGICAL ANTHROPOLOGYno. 3 (2022): 431-443
AMERICAN JOURNAL OF BIOLOGICAL ANTHROPOLOGY (2022): 194-194
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AMERICAN JOURNAL OF BIOLOGICAL ANTHROPOLOGY (2022): 24-24
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作者统计
#Papers: 249
#Citation: 13119
H-Index: 64
G-Index: 110
Sociability: 7
Diversity: 3
Activity: 24
合作学者
合作机构
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