基本信息
浏览量:94
职业迁徙
个人简介
The focus of our work is on the use of dendritic cells (DC) as immunotherapeutic vaccines against melanoma and other malignancies. DC are extremely potent antigen presenting cells (APC) that express MHC class I and class II molecules and an array of costimulatory molecules that are required for the activation of naïve T cells. Thus, DC make ideal candidates as vaccine delivery systems for the generation of immune responses against tumors. Recent studies have demonstrated that many patients make immune responses against their tumors, though they usually ultimately fail to control tumor outgrowth. Extensive investigations have identified many of the proteins that are the targets of these immune responses, and further defined the MHC class I and MHC class II-restricted peptides derived from tumor antigens that are presented to cytotoxic CD8+- and helper CD4+ T cells respectively. DC pulsed with such peptides are the basis of the vaccines that we are currently studying.
Recent studies in our laboratory have indicated that mice immunized with both MHC class I- and class II-restricted peptides derived from an antigen expressed by tumor results in greater control of tumor outgrowth as compared to mice immunized with the MHC class I-restricted peptide alone (Hwang et al, 2007). Further studies have indicated that tumor-specific memory CD4+ T cells enhance the activation, differentiation and, in particular, the infiltration of tumor by secondary CD8+ T cells.
Recent studies in our laboratory have indicated that mice immunized with both MHC class I- and class II-restricted peptides derived from an antigen expressed by tumor results in greater control of tumor outgrowth as compared to mice immunized with the MHC class I-restricted peptide alone (Hwang et al, 2007). Further studies have indicated that tumor-specific memory CD4+ T cells enhance the activation, differentiation and, in particular, the infiltration of tumor by secondary CD8+ T cells.
研究兴趣
论文共 137 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Remziye E Wessel, Nardin Ageeb,Joseph M Obeid,Ileana Mauldin, Kate A Goundry, Mahdin Hossain, Chad Lehman,Ryan D Gentzler,Nolan A Wages,Craig L Slingluff,Timothy N.J. Bullock,Sepideh Dolatshahi,
biorxiv(2024)
The Analystno. 9 (2024): 2609-2620
Elsevier eBookspp.129-156.e6, (2024)
引用0浏览0引用
0
0
Gynecologic Oncology (2023): S5
引用0浏览0WOS引用
0
0
Journal for ImmunoTherapy of Cancerno. 11 (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
引用0浏览0引用
0
0
Journal of leukocyte biology (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn