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The immune system is intricately involved in all aspects of cancer. While many neoplastic cells are detected and eliminated by immune cells, inflammation is also a fundamental driver of tumourigenesis. Our group is interested in understanding the basic immune-regulatory mechanisms in cancer, focusing on a new type of immune-regulatory cell, called the group 2 innate lymphoid cell (ILC2). More specifically, ILC2 are known to directly influence many pro- and anti-cancer immune pathways, making this cell a challenging but potentially important target to investigate. We are using, and developing, cutting-edge reagents to study how ILC2-driven inflammation is involved in cancer. This research will reveal potential new avenues for immunotherapy.
Our research at the CRUK Cambridge Institute leverages our expertise in ILC biology and innate/adaptive immune crosstalk, and many of the strengths of the institute:
Imaging inflammation and cancer
Developing new immune-targeted reagents
Single cell technologies to study the tumour niche
Close interactions with Addenbrooke’s and Papworth hospital
Our research at the CRUK Cambridge Institute leverages our expertise in ILC biology and innate/adaptive immune crosstalk, and many of the strengths of the institute:
Imaging inflammation and cancer
Developing new immune-targeted reagents
Single cell technologies to study the tumour niche
Close interactions with Addenbrooke’s and Papworth hospital
研究兴趣
论文共 62 篇作者统计合作学者相似作者
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Julie Stockis,Thomas Yip, Shwetha Raghunathan,Celine Garcia,Sheng Lee, Charlotte Simpson, Silvain Silvain, Martijn J. Schuijs, Joaquin Araos,Shaun Png, Gianmarco Raddi, Orian Bricard,
biorxiv(2024)
Munetomo Takahashi, Ty So,Kate Williamson,Zhaleh Hosseini,Katarzyna Kania, Michelle Ruhle,Tiffeney Mann, Martijn J. Schujis,Paul Coupland,Dean Naisbitt,Timotheus Y.F. Halim,Paul A. Lyons,
biorxiv(2023)
Pancreatologyno. 4 (2023): e12-e13
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T. Yip,Sheng Lee,Julie Stockis,Céline Garcia, Shwetha Raghunathan, Bram Lim, Silvain Pinaud,Shaun Png,Timotheus Y.F. Halim
Cancer Researchno. 7_Supplement (2023): 2341-2341
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Shwetha Raghunathan,J. Stockis, C. Garcia, T. Yip,E. Serrao, H. Rodewald,A. McKenzie,K. Brindle,T. Halim
biorxiv(2021)
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