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Bio
I obtained a BSc in Biomedical Sciences from Utrecht University, in the Netherlands. In my final year, I decided to pursue a Master’s in Molecular and Cellular Life Sciences, also at Utrecht University. I directed my Master’s programme towards Virology and conducted two research projects. The major project, working with Dr. Raoul de Groot and Huib Rabouw MSc., centred on the molecular and functional characterisation of a coronavirus accessory protein, in particular its role in integrated stress response antagonism. My minor project, on placement at the University of Oxford with Prof. Peter Simmonds and Dr. Isabelle Dietrich, focused on the influence of the secondary and higher-order structure of viral RNA on persistence in its natural hosts. Finally, I wrote my Master’s thesis under the supervision of Prof. Frank van Kuppeveld and Linda Visser MSc., on the role of ISG15 in the intra- and extracellular, innate and adaptive immune responses, the structural similarities and differences between it and diubiquitins, and the specificity determinants of viral deubiquitinases/deISGylases.
My PhD project at the University of Leeds is under supervision of Dr. John Barr and Dr. Thomas Edwards and is part of the European Union's HONOURs training network (Marie Skłodowska-Curie Action); https://honours.eu/home. My project focuses on the expression and structural elucidation of nucleoproteins and nucleocapsid complexes of various emerging zoonotic viruses, using protein crystallography and cryo-electron microscopy. Of primary interest are members of the Bunyaviridae and Paramyxoviridae families. Once resolved, the molecular structures of these proteins may improve our mechanistic understanding of the viral life cycle and aid in the design of novel therapeutics, directly targeting these proteins or the interactions with their binding partners.
Research Interests
Papers共 4 篇Author StatisticsCo-AuthorSimilar Experts
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Rabouw, Huib H.,Visser, Linda J.,Passchier, Tim C.,Langereis, Martijn A.,Liu, Fan,Giansanti, Piero,van Vliet, Arno L. W., Dekker, José G.,van der Grein, Susanne G., Saucedo, Jesús G.,Anand, Aditya A.,Trellet, Mikael E.,
Jelke Jan Fros,Isabelle Dietrich, Kinda Alshaikhahmed,Tim Casper Passchier,David John Evans,Peter Simmonds
crossref(2017)
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