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长期从事消化道肿瘤(主要是肠道肿瘤)的诊断治疗与研究工作,主要有两个研究方向,一是通过研究与消化道肿瘤密切相关的Wnt、EGFR、NF-κB等信号通路及通路中的关键信号分子(如Naked2, EGFR, PLD, BID, Exo70, HNF4α, LKB1),探索它们在消化道肿瘤发生发展中的调控作用机制及生理学意义,从而阐释消化道肿瘤发生发展、侵袭转移的具体分子机理;二是新型肠癌诊断试剂与治疗药物的开发。既通过肿瘤分子药物靶点去筛选抗肿瘤传统中药,又可以检测抗癌中药单体对肿瘤靶点的效果,筛选具有明显抗癌活性的中药单体并加以利用改造,开发靶向性抗肿瘤药物。同时在基因、蛋白水平上寻找胃肠道肿瘤的早期诊断标志物,为胃肠道肿瘤的诊断提供新思路和新方法。
Research Interests
Papers共 98 篇Author StatisticsCo-AuthorSimilar Experts
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 1 (2024): 142
Jingzhou Xiang,Bowen Zheng,Lingying Zhao, Yuting He, Fanzhuoran Lou,Runyang Li, Miao Fu, Xintian Huang,Wenqing Zhang,Xiaoting Hong,Li Xiao,Tianhui Hu
CANCERSno. 2 (2024): 336
Jianhui Zhou,Beibei Xu,Qianwen Shen, Zhenwei Zhang, Yuting Hu, Mengxue Wang,Yongcheng Su,Ziyu Lei,Wenqing Zhang,Tao Liu,Hong Liu,Tianhui Hu,
EMBO reportsno. 11 (2023)
biorxiv(2023)
JHEP REPORTSno. 11 (2023): 100883
Jihuan Hou,Han Wu,Beibei Xu,Jin Shang, Xuechun Xu, Guixia Li, Haoran Zhang,Wenqing Zhang,Yabin Deng,Xiaoting Hong,Tianhui Hu,Mingqing Zhang,
International journal of molecular sciencesno. 4 (2023): 3486-3486
Research Square (Research Square) (2023)
Jia-Li Zhou, Jia-Chen Bao,Xu-Ying Liao, Yi-Jia Chen,Lin-Wei Wang,Yan-Yun Fan,Qin-Yu Xu,Lan-Xiang Hao, Kun-Jian Li, Ming-Xian Liang,Tian-Hui Hu,Zheng-Jin Liu,
BMC public healthno. 1 (2023): 2507-2507
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