基本信息
浏览量:18
职业迁徙
个人简介
My research interest included immune response following sepsis in rodent models as well as in critically ill pediatric patients. I have worked over the past 25 years studying the role of gastrointestinal associated lymphoid tissue (GALT) in sepsis and burn injury, the relation between coagulopation and inflammation in sepsis and Systemic Inflammatory Response (SIRS), and the role of aldo-ketoreductase Aldose Reductase (AR) in inducing lung injury following septic peritonitis. We have used various techniques to induce septic inflammatory response in both adult rodents as well as rodent pups. These techniques included intra-peritoneal administration of bacteria, lipopolysachharide (LPS), and insertion of rodent fecal pellets containing bacteria into the peritoneal cavity to induce peritonitis as well as cecal ligation and puncture to induce septic peritonitis. My research included working with transgenic adult mice to understand how they differed from their wild type counterparts in their cardiovascular and pulmonary responses following septic peritonitis. In addition, I’m involved in translational research involving pediatric patients. We have investigated the role of peripheral neutrophil AR expression on the outcome in pediatric patients admitted to pediatric critical care unit in acute respiratory failure within the first 24 hours of admission. Another translational ongoing research project involves investigating the role of lymphocytes in viral lower respiratory tract infection is helping us to understand the lung adaptive immunological response following viral inflammation and contrast that with bacterial inflammation that I have studied in the past few years.
In the recent past I have developed my interest in critical care nutrition by working with PCCU nutritional support group and developed PICU enteral nutrition guidelines to be used in both Komansky and Morgan-Stanley Children’s Hospital campuses. We have introduced Indirect Calorimeter (IC) in assessing the resting energy expenditure in critically ill children which has helped us to tailor appropriately nutritional needs of critically ill children. We have extended IC use to patients admitted to pediatric floor. We plan to undertake outcome studies in this area.
研究兴趣
论文共 63 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
P L T Girija,Nithya Sivan,Pallavi Naik,Yamini Agalya Murugavel,Thyyar M Ravindranath, Krishnaswami Cv
Journal of Ayurveda and integrative medicineno. 1 (2021): 100466-100466
Pediatric Critical Care Medicineno. 1 (2020): 107-108
Thomas J Connors,Thyyar M Ravindranath,Kara L Bickham,Claire L Gordon, Feifan Zhang,Bruce Levin, John S Baird,Donna L Farber
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn