基本信息
浏览量:3
职业迁徙
个人简介
Research
Gap junction functions defined by genetic diseases and gene knockouts.
Intercellular channels present in gap junctions allow cells to share small molecules and thus coordinate a wide range of behaviors. In vertebrates, a large family of genes known as connexins (Cx) encodes these gap junctional channels, and mutations in human connexins underlie a variety of diseases, including deafness, skin diseases (keratodermas), and lens cataracts. We are interested in how different members of the connexin family fulfill unique functions in tissue homeostasis, and in how intercellular channel activity is regulated by intracellular signal transduction cascades. We study the consequences of disease causing mutations on the functional behavior of channels using in vitro assays of channel permeation and gating followed by the generation of genetically engineered mice where genes have been deleted or mutated to create models of human disease.
研究兴趣
论文共 242 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Unfallchirurgie (Heidelberg, Germany)no. 3 (2024): 171-179
Die Unfallchirurgieno. 3 (2024): 171-179
AGING CELLno. 2 (2024): e14038-e14038
medRxiv (Cold Spring Harbor Laboratory) (2023)
引用0浏览0引用
0
0
The journal of trauma and acute care surgeryno. 4 (2023): 618-622
Surgical technology international (2023)
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 13 (2023): 37
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn