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RNA functions not only as a carrier of genetic information, but also as a catalyst and guide for the processing or regulation of other RNA molecules. Cells have evolved mechanisms to sense aberrant sequence, structure, and chemical modification of nucleic acids by a process known as innate immunity. Tuschl is investigating these mechanisms in human cells with the goal of developing treatments for genetic and inflammatory diseases.
Eukaryotic cells express a variety of classes of small RNA molecules. The Tuschl lab has identified these classes and their many members using various RNA-sequencing (RNA-seq) techniques. Their discoveries include the molecular characterization of small interfering RNAs (siRNAs), a class of double-stranded, 21-nucleotide-long molecules that guide sequence-specific gene silencing. Tuschl was the first to demonstrate their utility for knocking down human gene expression, leading to the development of a new class of therapeutics.
Research Interests
Papers共 430 篇Author StatisticsCo-AuthorSimilar Experts
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Lupus Science and Medicineno. Suppl 2 (2024)
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Evan D Paul, Barbora Huraiová, Natália Valková,Natalia Birknerova, Daniela Gábrišová, Sona Gubova, Helena Ignačáková, Tomáš Ondris, Silvia Bendíková, Jarmila Bíla,Katarína Buranovská,Diana Drobná,
medRxiv the preprint server for health sciences (2023)
crossref(2023)
Susanta Chatterjee,Parisa Naeli,Nicole Simms,Aitor Garzia,Angela Hackett, Kelsey Coyle,Patric Harris Snell, Tom McGirr, Tanvi Nitin Sawant, Kexin Dang, Zornitsa V. Stoichkova,Tommy Alain,
biorxiv(2023)
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Author Statistics
#Papers: 431
#Citation: 133187
H-Index: 123
G-Index: 303
Sociability: 7
Diversity: 4
Activity: 101
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