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Dr. Jessell's research has focused on the development of functional circuitry in the vertebrate central nervous system. Using the sensory-motor reflex circuit in the spinal cord as a model system, his work has defined many of the cellular and molecular mechanisms and principles that determine the formation of neuronal connections and the assembly of functional circuitry. His studies have shown how insights from normal pathways of neuronal specification can be used to direct embryonic stem cells to form functional neurons that can integrate into brain circuits. These findings have implications for the reconstruction of circuits that have been damaged through trauma or neurodegenerative disease.
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Papers共 291 篇Author StatisticsCo-AuthorSimilar Experts
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crossref(2024)
biorxiv(2022)
Scientific reportsno. 1 (2021): 19861-19861
biorxiv(2021)
The Journal of neuroscience : the official journal of the Society for Neuroscienceno. 22 (2019): 4252-4267
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