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Research Interests
Organic and Organometallic Chemistry — Natural product total synthesis, Synthetic organic methodology development, Catalyst design.
Synthesis is the unifying theme of our group—total synthesis, new methods for organic synthesis, and the synthesis of new catalyst architectures. In the former area, we are actively pursuing innovative solutions to the total chemical synthesis of a number of complex, biologically active natural products. The identification and realization of powerfully simplifying transformations, which allow for rapid access to the target structure, is a major driving force of our research program. In addition, the interplay between structure and function, and the ability to “re-engineer” natural product structures in an attempt to increase their applicability to problems in biology and medicine is also of particular interest and target selection typically reflects this objective. In a second area, we are interested in exploring unorthodox approaches to catalyst design for transition metal-mediated processes. Traditional metal/ligand catalyst systems often feature rigid ligands with well-defined steric and electronic parameters. We are interested in the synthesis and study of fluxional ligand structures with the potential to access many different steric and electronic states during catalysis. We will use the tools of organic and organometallic chemistry to synthesize and characterize the behavior of these systems.
Organic and Organometallic Chemistry — Natural product total synthesis, Synthetic organic methodology development, Catalyst design.
Synthesis is the unifying theme of our group—total synthesis, new methods for organic synthesis, and the synthesis of new catalyst architectures. In the former area, we are actively pursuing innovative solutions to the total chemical synthesis of a number of complex, biologically active natural products. The identification and realization of powerfully simplifying transformations, which allow for rapid access to the target structure, is a major driving force of our research program. In addition, the interplay between structure and function, and the ability to “re-engineer” natural product structures in an attempt to increase their applicability to problems in biology and medicine is also of particular interest and target selection typically reflects this objective. In a second area, we are interested in exploring unorthodox approaches to catalyst design for transition metal-mediated processes. Traditional metal/ligand catalyst systems often feature rigid ligands with well-defined steric and electronic parameters. We are interested in the synthesis and study of fluxional ligand structures with the potential to access many different steric and electronic states during catalysis. We will use the tools of organic and organometallic chemistry to synthesize and characterize the behavior of these systems.
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论文共 82 篇作者统计合作学者相似作者
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Andre Sanchez, Anjali Gurajapu,Wentao Guo,Wang-Yeuk Kong,Croix J Laconsay,Nicholas S Settineri,Dean J Tantillo,Thomas J Maimone
Journal of the American Chemical Societyno. 24 (2023): 13452-13461
JACS Auno. 10 (2023): 2883-2893
Flor A Gowans,Danny Q Thach,Yangzhi Wang, Belen E Altamirano Poblano,Dustin Dovala,John A Tallarico,Jeffrey M McKenna,Markus Schirle,Thomas J Maimone,Daniel K Nomura
bioRxiv : the preprint server for biology (2023)
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