基本信息
浏览量:3
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
AREAS OF INTEREST
Molecular, cellular, and behavioral architecture of memory formation.
RESEARCH OVERVIEW
My laboratory is interested in understanding how the brain acquires, stores and retrieves information. We explore these questions using a simple model system, the marine mollusk Aplysia californica, because its nervous system affords significant advantages for identifying synaptic, biophysical, and molecular changes underlying memory formation.
We have two broad research programs. The first examines the temporal domains of memory. In this work we have identified three mechanistically distinct phases of synaptic facilitation in the CNS (short-term, intermediate-term and long-term), each of which predicted the existence and molecular features of distinct temporal phases of behavioral memory for sensitization. We are currently exploring the role of specific elements in the molecular cascades that underlie memory formation for sensitization, with a specific focus on (i) MAPK and G-protein signaling pathways, (ii) molecular "routing" of these elements to different cellular compartments, and (iii) synaptic and nuclear signaling underlying long-term memory formation.
The second program examines the role of growth factors in memory formation, with a specific focus on neurotrophins, because they are critically involved in developmental processes such as neuronal cell survival, growth, and differentiation, as well as in adult synaptic plasticity contributing to learning and memory. We have recently cloned and characterized a novel neurotrophin, Aplysia cysteine-rich neurotrophic factor (apCRNF), which is highly enriched in the CNS, and can facilitate MAPK activation and the induction of long-term synaptic facilitation, both of which are critically engaged in memory formation. We are currently exploring two guiding hypotheses: (i) Different families of GFs initiate signaling in distinct cellular compartments to contribute to different phases of memory formation and its underlying synaptic plasticity, and (ii) GFs re-employ dynamic molecular signaling cascades known to be engaged in development in the service of memory formation and synaptic plasticity.
Molecular, cellular, and behavioral architecture of memory formation.
RESEARCH OVERVIEW
My laboratory is interested in understanding how the brain acquires, stores and retrieves information. We explore these questions using a simple model system, the marine mollusk Aplysia californica, because its nervous system affords significant advantages for identifying synaptic, biophysical, and molecular changes underlying memory formation.
We have two broad research programs. The first examines the temporal domains of memory. In this work we have identified three mechanistically distinct phases of synaptic facilitation in the CNS (short-term, intermediate-term and long-term), each of which predicted the existence and molecular features of distinct temporal phases of behavioral memory for sensitization. We are currently exploring the role of specific elements in the molecular cascades that underlie memory formation for sensitization, with a specific focus on (i) MAPK and G-protein signaling pathways, (ii) molecular "routing" of these elements to different cellular compartments, and (iii) synaptic and nuclear signaling underlying long-term memory formation.
The second program examines the role of growth factors in memory formation, with a specific focus on neurotrophins, because they are critically involved in developmental processes such as neuronal cell survival, growth, and differentiation, as well as in adult synaptic plasticity contributing to learning and memory. We have recently cloned and characterized a novel neurotrophin, Aplysia cysteine-rich neurotrophic factor (apCRNF), which is highly enriched in the CNS, and can facilitate MAPK activation and the induction of long-term synaptic facilitation, both of which are critically engaged in memory formation. We are currently exploring two guiding hypotheses: (i) Different families of GFs initiate signaling in distinct cellular compartments to contribute to different phases of memory formation and its underlying synaptic plasticity, and (ii) GFs re-employ dynamic molecular signaling cascades known to be engaged in development in the service of memory formation and synaptic plasticity.
研究兴趣
论文共 123 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Proceedings of the National Academy of Sciences of the United States of Americano. 40 (2023): e2300595120-e2300595120
Neuronno. 4 (2020): 590-593
Scientific reportsno. 1 (2019): 14379-14379
加载更多
作者统计
#Papers: 124
#Citation: 4473
H-Index: 37
G-Index: 63
Sociability: 5
Diversity: 0
Activity: 0
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn