基本信息
浏览量:2
职业迁徙
个人简介
Research Interests
We are exploring structured RNA as (1) a drug target and a material for (2) self-assembling nano-architectures.
(1) Unique three-dimensional folds enable noncoding RNAs to participate as key players in cellular processes and provide opportunities to develop selective small molecules as inhibitors and modulators of ncRNA function. Selective ligands of ncRNA targets have a potential to expand the existing repertoire of protein-directed therapeutics. We use molecular biology and biochemistry approaches to discover and validate RNA targets, biophysical methods to study their structure and discover interactions with ligands, as well as synthetic organic chemistry to prepare and optimize RNA-binding molecules.
(2) Nucleic acid nanotechnology aims to design and build functional materials and devices that self-assemble through base pairing and folding of DNA or RNA strands. We develop crystal structure-guided design and screening approaches to create complex nucleic acid nano-architectures that self-assemble from RNA motifs as architectural joints and DNA building blocks as functional modules for modification and chemical diversification. To obtain complex soft materials, we devise additive and subtractive manufacturing techniques for self-assembling nucleic acid components.
We are exploring structured RNA as (1) a drug target and a material for (2) self-assembling nano-architectures.
(1) Unique three-dimensional folds enable noncoding RNAs to participate as key players in cellular processes and provide opportunities to develop selective small molecules as inhibitors and modulators of ncRNA function. Selective ligands of ncRNA targets have a potential to expand the existing repertoire of protein-directed therapeutics. We use molecular biology and biochemistry approaches to discover and validate RNA targets, biophysical methods to study their structure and discover interactions with ligands, as well as synthetic organic chemistry to prepare and optimize RNA-binding molecules.
(2) Nucleic acid nanotechnology aims to design and build functional materials and devices that self-assemble through base pairing and folding of DNA or RNA strands. We develop crystal structure-guided design and screening approaches to create complex nucleic acid nano-architectures that self-assemble from RNA motifs as architectural joints and DNA building blocks as functional modules for modification and chemical diversification. To obtain complex soft materials, we devise additive and subtractive manufacturing techniques for self-assembling nucleic acid components.
研究兴趣
论文共 140 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
David Schmit, Urszula Milewicz,Mark A. Boerneke, Scott Burley,Kevin Walsworth, Joann Um,David Hecht,Thomas Hermann,B. Mikael Bergdahl
Kevin Walsworth, Anthony Simon, Tyler Nelson Hall, Josiah Molina,Anastasiya Bender,Thomas Hermann,Mikael Bergdahl
引用0浏览0引用
0
0
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2017)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn