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Bio
Environmentally exposed surfaces in humans are colonized by a vast number of foreign microbes (the commensal microbiota) and these organisms play a key role in regulating mucosal and systemic immune function. Disruption of this relationship is linked to a wide variety of diseases and immune dysfunctions, including chronic inflammatory conditions at the mucosa, autoimmunity and increased susceptibility to infection by bacteria, viruses and parasites. There remains, however, a major gap in understanding the mechanistic basis for the influence of the commensal microbiota on immune function, especially systemic immunity. The broad theme of my research, therefore, is to understand how programming of innate immunity by the microbiota influences host responses to bacterial infection and vaccination, and how changes to the composition of the microbiota disrupts these responses.
Research Interests
Papers共 172 篇Author StatisticsCo-AuthorSimilar Experts
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Christine K I Jordan,Thomas B Clarke
Chryso Christodoulou,Thomas B Clarke
Proceedings of the National Academy of Sciences of the United States of Americano. 25 (2024): e2408800121-e2408800121
Olivia G. King, Alexander Y. Yip,Victoria Horrocks,Jesús Miguéns Blanco,Julian Marchesi,Benjamin H. Mullish,Thomas B. Clarke, Julie A. McDonald
Gastroenterologyno. 5 (2024): S-584
Protein science : a publication of the Protein Societyno. 7 (2024): e5073-e5073
Alexander Y. G. Yip, Olivia G. King,Oleksii Omelchenko,Sanjana Kurkimat,Victoria Horrocks,Phoebe Mostyn,Nathan Danckert,Rohma Ghani,Giovanni Satta,Frances J. Davies,Thomas B. Clarke,Benjamin H. Mullish,
Christine K I Jordan,Rebecca L Brown, Max L Y Larkinson,Richard P Sequeira,Andrew M Edwards,Thomas B Clarke
Microorganismsno. 5 (2023): 1166-1166
Protein science : a publication of the Protein Societyno. 11 (2023)
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