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The research in our lab is carried out by a team of graduate and undergraduate researchers. The research primarily focuses on the role of signal transduction pathways in normal and disease physiology. Much of our research involved projects centered on transcription factor NF-κB. In one project, we seek to understand the cellular and molecular mechanisms by which altered NF-κB activity contributes to a variety of human diseases, especially lymphoid cell cancers and immunodeficiencies. For example, we have found that many human B-cell lymphomas have chronically high levels of nuclear NF-κB activity that is required for their growth and survival. Conversely, some human immunodeficiency diseases are due to mutations that reduced NF-κB signaling in response to cytokines or pathogens.
In current collaborative studies with Drs. Adrian Whitty and Karen Allen in the Chemistry Department at BU, we are characterizing the structure and function of the protein NEMO, which is an upstream scaffold protein in the NF-κB pathway and is mutated in certain human immunodeficiencies. We have recently found that NEMO normally undergoes a conformational change that is required for its signaling activity and that some human disease mutations affect the ability of NEMO to undergo this conformational change. For some of these studies, we are using cell lines with novel CRISPR-based genome editing of the NEMO gene.
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bioRxiv the preprint server for biology (2024)
Maria Valadez-Ingersoll,Pablo J Aguirre Carrion, Caoimhe A Bodnar,Niharika A Desai,Thomas D. Gilmore,Sarah W. Davies
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Sarah Davies, Maria Ingersoll, Niharika Desai, Kate Mansfield,Phillip Cleves,Hanny Rivera,Leah Williams,Rachel Wright,Thomas Gilmore
INTEGRATIVE AND COMPARATIVE BIOLOGY (2023): S105-S105
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Christopher J. DiRusso,Anthony M. DeMaria, Judy Wong, Jack J. Jordanides,Adrian Whitty, Karen N. Allen,Thomas D. Gilmore
Reference Module in Life Sciences (2022)
Communications Biologyno. 1 (2022): 698-10
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