基本信息
浏览量:6
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
The overall goal of our research and clinical care is to help people with diabetes maintain good vision. We approach the problem by combining evaluations of patients and laboratory studies to determine how diabetes impacts the eye and the molecular mechanisms that give rise to these changes, and to develop new therapies.
Laboratory studies are testing the general hypothesis that altered growth factor signaling, combined with inflammation, impairs the survival of retinal nerve cells. We discovered the retina possesses a highly active insulin receptor signaling system and its activity is reduced by diabetes, and restored with systemic and intraocular insulin treatment. The retinal insulin receptor signaling pathway, including Akt and mTOR kinases, serves to maintain retinal cell survival in the face of diabetes, and insulin treatment reduces the rate of neuron apoptosis, but the activity of the pathway is impaired by excess nutrients such as glucose. Current studies are also investigating the role of diabetes on retinal protein synthesis and the underlying metabolic pathways.
Clinical studies are examining the impact of diabetes on visual function and retinal structure, and the impact of novel therapies, in patients with diabetic retinopathy. We hope to develop quantitative and sensitive measures of diabetic retinopathy so that treatment can be initiated while vision remains intact. Additional work is aimed at restoring vision in persons who have completed treatment for their retinopathy but whose vision is still reduced.
We welcome inquiries from prospective students and post-doctoral scholars who may wish to work with us, and from patients who are interested in the work.
Laboratory studies are testing the general hypothesis that altered growth factor signaling, combined with inflammation, impairs the survival of retinal nerve cells. We discovered the retina possesses a highly active insulin receptor signaling system and its activity is reduced by diabetes, and restored with systemic and intraocular insulin treatment. The retinal insulin receptor signaling pathway, including Akt and mTOR kinases, serves to maintain retinal cell survival in the face of diabetes, and insulin treatment reduces the rate of neuron apoptosis, but the activity of the pathway is impaired by excess nutrients such as glucose. Current studies are also investigating the role of diabetes on retinal protein synthesis and the underlying metabolic pathways.
Clinical studies are examining the impact of diabetes on visual function and retinal structure, and the impact of novel therapies, in patients with diabetic retinopathy. We hope to develop quantitative and sensitive measures of diabetic retinopathy so that treatment can be initiated while vision remains intact. Additional work is aimed at restoring vision in persons who have completed treatment for their retinopathy but whose vision is still reduced.
We welcome inquiries from prospective students and post-doctoral scholars who may wish to work with us, and from patients who are interested in the work.
研究兴趣
论文共 17 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Sarah Weber,Thomas Gardner,Chris Gates, Nick Carruthers,David Zacks,Jeffrey Yu,Yuanjun Zhao,Jeffrey Sundstrom
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
引用0浏览0引用
0
0
JOURNAL OF CLINICAL MEDICINEno. 6 (2021): 1254
加载更多
作者统计
#Papers: 17
#Citation: 1057
H-Index: 9
G-Index: 12
Sociability: 5
Diversity: 2
Activity: 10
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn