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The relatively recent discovery that double-stranded RNA (dsRNA) and its functional derivatives (siRNA) could mediate potent and specific gene silencing in a wide variety of species sparked a revolution in molecular biology. While first discovered in C. elegans, now a recognized group of related phenomena broadly conserved in eukaryotes is generally known as RNA-mediated interference, or RNAi. Central actors to these phenomena are small ~18-25nt non-coding RNAs which are matured by the RNase type III Dicer, and assembled with the Argonaute proteins into a variety of effector silencing complexes.
The relatively recent discovery that double-stranded RNA (dsRNA) and its functional derivatives (siRNA) could mediate potent and specific gene silencing in a wide variety of species sparked a revolution in molecular biology. While first discovered in C. elegans, now a recognized group of related phenomena broadly conserved in eukaryotes is generally known as RNA-mediated interference, or RNAi. Central actors to these phenomena are small ~18-25nt non-coding RNAs which are matured by the RNase type III Dicer, and assembled with the Argonaute proteins into a variety of effector silencing complexes.
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论文共 64 篇作者统计合作学者相似作者
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Elva Vidya,Yasaman Jami-Alahmadi, Adarsh K. Mayank, Javeria Rizwan, Jia Ming Stella Xu, Tianhao Cheng,Rania Leventis,Nahum Sonenberg,James Wohlschlegel, Maria Vera,Thomas Duchaine
biorxiv(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Jung-Hyun Choi, Jun Luo,Geoffrey G. Hesketh, Shuyue Guo, Angelos Pistofidis,Reese Jalal Ladak, Yuxin An,Tommy Alain,T. Martin Schmeing,Anne-Claude Gingras,Thomas Duchaine,Xu Zhang,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Elva Vidya,Thomas F Duchaine
Gabrielle Perron, Mohan Amaravadi, Cynthia Tseng,Pouria Jandaghi, Elham Moslemi,Tamiko Nishimura, Maryam Rajaee, Rached Alkallas,Bruce Culbertson,Kristle Garcia,Ian R. Watson,Hani Goodarzi,
Zenodo (CERN European Organization for Nuclear Research) (2022)
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