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个人简介
Dr. Carey's hearing research at the KHRI focuses on mechanisms of autoimmune hearing loss mediated by antibodies to inner ear antigens. His lab discovered, characterized and cloned a gene that encodes an inner ear antigen called CTL2 (choline transporter-like protein 2), that is the target of antibody induced hearing loss. His team is using recombinant human CTL2 to develop an improved test for diagnosis of autoimmune hearing loss. To develop a better understanding of the mechanisms of autoimmune hearing loss and to determine the role of CTL2 (also called SLC44A2) in tissue homeostasis in the inner ear and in other tissues, his lab developed a CTL2/SLC44A2 knock out mouse and are categorizing the hearing deficits and anatomical effects of loss of this protein on the inner ear and other tissues.
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Monique Verhaegen,Joshua A. Bauer, Cristina Martín de la Vega,Guoping Wang,Keith G. Wolter, J. Chadwick Brenner,Zaneta Nikolovska-Coleska, Audrey Bengtson,Rajan Nair,James T. Elder, Matt Van Brocklin,Thomas E. Carey,
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