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The relatively recent discovery that double-stranded RNA (dsRNA) and its functional derivatives (siRNA) could mediate potent and specific gene silencing in a wide variety of species sparked a revolution in molecular biology. While first discovered in C. elegans, now a recognized group of related phenomena broadly conserved in eukaryotes is generally known as RNA-mediated interference, or RNAi. Central actors to these phenomena are small ~18-25nt non-coding RNAs which are matured by the RNase type III Dicer, and assembled with the Argonaute proteins into a variety of effector silencing complexes.
The relatively recent discovery that double-stranded RNA (dsRNA) and its functional derivatives (siRNA) could mediate potent and specific gene silencing in a wide variety of species sparked a revolution in molecular biology. While first discovered in C. elegans, now a recognized group of related phenomena broadly conserved in eukaryotes is generally known as RNA-mediated interference, or RNAi. Central actors to these phenomena are small ~18-25nt non-coding RNAs which are matured by the RNase type III Dicer, and assembled with the Argonaute proteins into a variety of effector silencing complexes.
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Papers共 64 篇Author StatisticsCo-AuthorSimilar Experts
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Boris J.A. Dyakov, Simon Kobelke, B. Raktan Ahmed, Mingkun Wu, Jonathan F. Roth, Vesal Kasmaeifar, Zhen-Yuan Lin,Ji-Young Youn, Caroline Thivierge,Kieran R. Campbell,Thomas F. Duchaine,Benjamin J. Blencowe,
biorxiv(2024)
Elva Vidya,Yasaman Jami-Alahmadi, Adarsh K. Mayank, Javeria Rizwan, Jia Ming Stella Xu, Tianhao Cheng,Rania Leventis,Nahum Sonenberg,James A. Wohlschlegel,Maria Vera,Thomas F. Duchaine
biorxiv(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Parisa Naeli,Xu Zhang, Patric Leo Harris Snell,Susanta Chatterjee,Muhammad Kamran,Reese Jalal Ladak,Nick Orr,Thomas F Duchaine,Nahum Sonenberg,Seyed Mehdi Jafarnejad
crossref(2023)
Jung-Hyun Choi,Jun Luo,Geoffrey G. Hesketh, Shuyue Guo, Angelos Pistofidis,Reese Jalal Ladak,Yuxin An,Tommy Alain,T. Martin Schmeing,Anne-Claude Gingras,Thomas Duchaine,Xu Zhang,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Elva Vidya,Thomas F Duchaine
Gabrielle Perron, Mohan Amaravadi, Cynthia Tseng,Pouria Jandaghi, Elham Moslemi,Tamiko Nishimura, Maryam Rajaee, Rached Alkallas,Bruce Culbertson,Kristle Garcia,Ian R. Watson,Hani Goodarzi,
Zenodo (CERN European Organization for Nuclear Research) (2022)
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