基本信息
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Career Trajectory
Bio
After studying Biochemistry in Geneva, in 1987 I started my doctoral thesis at the Institute of Cell Biology of the ETH in Zurich, Switzerland, with Jean-Claude Perriard, working on muscle cell cytoarchitecture. From 1991, I was a postdoc in the Biochemistry Department at Stanford University, USA, with Suzanne Pfeffer, unraveling the function of Rab GTPases in endosomal membrane trafficking. In 1995, I joined the Max-Planck-Institute for Medical Research in Heidelberg, Germany, as an independent group leader in Wolfhard Almers’s department.
There we started deciphering cellular and molecular mechanisms of endocytosis and phagocytosis, using the social amoeba Dictyostelium as a model system. In 2001, I was appointed as a lecturer at the Department of Biological Sciences at Imperial College London, UK. In 2004, I joined the Department of Biochemistry of the University of Geneva as a senior lecturer. Since then, the investigations have focused more heavily on the interface between host and pathogens, especially mycobacteria as they reprogramme the otherwise bactericidal phagocytic cells to establish a proliferation niche.
The major aim of the Soldati group is to understand the cooperation of signalling, cytoskeleton and membrane trafficking in phagocytosis and its relevance to the cell-autonomous immunity against pathogenic bacteria. To this end, we use the genetically and biochemically tractable Dictyostelium discoideum as a model organism. This amoeba is a professional phagocyte very similar in morphology and behaviour to mammalian phagocytes of the innate immune system, but which is ethically un-concerning, allowing significant progress to further the 3Rs cause. Besides significant milestones in the fundamental understanding of the complex relationships between the bacterium and its host, we have pioneered the use of the D. discoideum – M. marinum infection model to perform medium-throughput phenotypic screens to identify anti-infective compounds. Our studies reinforce the concept that amoebae represent a simple, powerful and 3R-compliant model system for the phenotypic screening of anti-infective compounds.
Research Interests
Papers共 220 篇Author StatisticsCo-AuthorSimilar Experts
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biorxiv(2024)
MSYSTEMSno. 2 (2024): e0132623-e0132623
The Journal of cell biologyno. 9 (2023)
Frontiers in Natural Products (2023)
PLANTA MEDICAno. 14 (2023): 1289-1289
Elsevier eBookspp.133-161, (2022)
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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