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个人简介
I earned my Ph.D in Neurophysiology in 2002 at the Université Claude Bernard in Lyon. I worked on the in vitro characterization of neurons located in the anterior hypothalamus responsible for the induction of slow-wave sleep. I discovered that these neurons and those in the waking systems are able to inhibit each other, illustrating a reciprocal inhibitory interaction. In 2003, I joined Jean Rossier’s laboratory at the Ecole Supérieure de Physique et de Chimie Industrielle (ESPCI), in Paris as a postdoctoral fellow. By coupling patch-clamp electrophysiological recordings with single-cell RT-PCR multiplex technique I uncovered cortical excitatory peptidergic pathways between GABAergic interneuron subtypes and glutamatergic pyramidal cells. Appointed as Associate Professor in Physiology at the ESPCI in 2005, I contributed to identifying and characterizing the role of neocortical GABAergic interneurons in mice.
In line with my previous work done during my PhD, I decided to create a team "Sleep Neuronal Networks" (SNN), in the lab unit UMR 8249, focusing on the understanding of cellular and molecular mechanisms responsible for the initiation and maintenance of slow-wave sleep. My team had been positively evaluated by the AERES committee (A/A+) as well as by the CSI-ESPCI. In particular, we demonstrated for the first time in mice that glucose could excite sleep-promoting neurons in the hypothalamus and thus facilitate sleep onset. After 4 years of leading the RNS team, I decided in 2016 to join the Memory Oscillations and Brain States (MOBS) team led by Dr. K. Benchenane in the Brain Plasticity laboratory whose goal is to understand the role of sleep on memory mechanisms. My objective in joining the MOBS team was to complement the knowledge and tools necessary for the development of new projects, in particular a project on the study of cortical control on the modulation of the activity of neural networks responsible for the alternation of wakefulness and sleep states. Presently, I combine in vivo and ex vivo electrophysiology tools with optogenetic stimulation in free-moving mice in order to better understand the neural mechanisms driving the alternation of sleep-waking states.
研究兴趣
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biorxiv(2022)
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Anastassios Karagiannis,Thierry Gallopin,Alexandre Lacroix,Fabrice Plaisier, Juliette Piquet,Hélène Geoffroy,Régine Hepp,Jérémie Naudé, Benjamin Le Gac,Richard Egger,Bertrand Lambolez,Dongdong Li,
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