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Bio
I am a medical physicist currently working on my research project devoted to structural neuroimaging in ataxias at the department of Neurology, State University of Campinas (UNICAMP). Since my graduation, I have been actively involved in studies looking at neuroimaging markers for inherited ataxias, with an especial interest in Friedreich’s ataxia (FA) and SCA3. Regarding ataxia research, I have some original contributions. I showed that structural damage in Machado-Joseph disease begins in the spinal cord, cerebellar peduncles and substantia nigra. Later in the disease course, damage extends diffusely to the brainstem and then to specific regions of cerebral cortex and subcortical white matter, which enabled me to create staging schemes to classify the degree of the pathological damage in Machado-Joseph disease. In addition, I was able to suggest that ATXN3-related neurodegeneration may follow a prion-like dissemination through central nervous system tracts. I also investigated the pattern of cerebral damage in pediatric FA patients using a multi-modal neuroimaging approach. In this study, I found results that challenge the concept that FA is a pure degenerative disease. A recent study published and cover of Movement Disorders (journal) led by me inside Enigma Ataxia supports such a concept. Indeed, the findings support the hypothesis that damage to the dorsal column and corticospinal tract follow distinct courses in FA: developmental abnormalities likely define the former, whereas the later may be both developmental and degenerative. In addition, progressive neurodegeneration in the corticospinal tract was consistent with the hypothesis that pyramidal tract damage in FA arises from a ‘dying back’ process. Lastly, in a Brazilian collaborative study, we were able to indicate that RFC1-related disease should no longer be considered a purely cerebellar and sensory pathway disorder, helping to explain some phenotypic traits recently recognized in the disease, but also indicate that the phenotypic spectrum related to RFC1 might be even broader. My work has recently expanded to also include development of novel analysis tools and specific MRI protocols using deep-learning algorithms. The goal of my research is to provide biomarkers for objective clinical assessment, treatment monitoring, and treatment targeting.
Research Interests
Papers共 118 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of neurology, neurosurgery, and psychiatryno. 7 (2024): 682-690
bioRxiv : the preprint server for biology (2024)
Camila C. Lobo, Guilherme S. O. Wertheimer,Gabriel S. Schmitt, Paula C. A. A. P. Matos,Thiago J. R. Rezende, Joyce M. Silva, Fabricio C. Borba, Fabricio D. Lima,Alberto R. M. Martinez,Orlando G. P. Barsottini,Jose Luiz Pedroso,Wilson Marques,
MOVEMENT DISORDERS CLINICAL PRACTICEno. 1 (2024): 45-52
medrxiv(2024)
Daiana Suelen Machado, Celiana Figueiredo Viana,Jose Luiz Pedroso,Orlando Graziani Povoas Barsottini,Pedro Jose Tomaselli,Wilson Marques,Thiago J. R. Rezende,Alberto R. M. Martinez,Marcondes Cavalcante Franca
CEREBELLUM (2024)
Daiana Suelen Machado, Celiana Figueiredo Viana,José Luiz Pedroso,Orlando Graziani Povoas Barsottini,Pedro José Tomaselli,Wilson Marques,Thiago J. R. Rezende,Alberto R. M. Martinez,Marcondes Cavalcante França
The Cerebellumpp.1-7, (2024)
Diogo H Shiraishi, Susmita Saha,Isaac M Adanyeguh,Sirio Cocozza,Louise A Corben,Andreas Deistung,Martin B Delatycki,Imis Dogan,William Gaetz,Nellie Georgiou-Karistianis, Simon Graf,Marina Grisoli,
medrxiv(2024)
Arquivos De Neuro-psiquiatria (2023)
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