基本信息
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职业迁徙
个人简介
Clinical Expertise
I am a clinical immunologist with many years of experience in evaluating human immune-mediated diseases. I served as Director of the Immunologic Monitoring and Cellular Products Laboratory (IMCPL) at the UPMC Hillman Cancer Center for 25 years and am currently serving as Interim Director. The IMCPL offers a broad spectrum of immunodiagnostic and monitoring assays for testing of patients with cancer. The laboratory also serves as a cGMP facility which generates cellular products for immunotherapy of patients with cancer and HIV.
Research Expertise
My research expertise is in cellular and molecular cancer immunology. My research has been focused on mechanisms of tumor-induced immunosuppression, cytokine networks, development of anticancer vaccines, immunobiology of human tumors and the role of natural immunity in the control of cancer progression. I study mechanisms of tumor escape from the host immune system and the development of therapies designed to eliminate tumor escape. Most recently, I have been investigating tumor-derived exosomes (TEX) and their role in cancer-induced immune suppression. I work with various subsets of human immune cells and study their functional impairments in patients with cancer. Tumor-mediated escape mechanisms are of special interest as are surrogate immunologic markers of prognosis and response to therapy in patients with cancer.
I am a clinical immunologist with many years of experience in evaluating human immune-mediated diseases. I served as Director of the Immunologic Monitoring and Cellular Products Laboratory (IMCPL) at the UPMC Hillman Cancer Center for 25 years and am currently serving as Interim Director. The IMCPL offers a broad spectrum of immunodiagnostic and monitoring assays for testing of patients with cancer. The laboratory also serves as a cGMP facility which generates cellular products for immunotherapy of patients with cancer and HIV.
Research Expertise
My research expertise is in cellular and molecular cancer immunology. My research has been focused on mechanisms of tumor-induced immunosuppression, cytokine networks, development of anticancer vaccines, immunobiology of human tumors and the role of natural immunity in the control of cancer progression. I study mechanisms of tumor escape from the host immune system and the development of therapies designed to eliminate tumor escape. Most recently, I have been investigating tumor-derived exosomes (TEX) and their role in cancer-induced immune suppression. I work with various subsets of human immune cells and study their functional impairments in patients with cancer. Tumor-mediated escape mechanisms are of special interest as are surrogate immunologic markers of prognosis and response to therapy in patients with cancer.
研究兴趣
论文共 837 篇作者统计合作学者相似作者
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Research square (2024)
Miroslaw J. Szczepanski,Malgorzata Czystowska,Marta Szajnik,Malgorzata Harasymczuk,Michael Boyiadzis, Aleksandra Kruk-Zagajewska,Witold Szyfter, Jan Zeromski,Theresa L. Whiteside
crossref(2023)
CLINICAL CANCER RESEARCHno. 18 (2023)
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Clinical Cancer Researchno. 18_Supplement (2023): PO-095
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Lisheng Ge,Dejan Baskic, Per Basse,Lazar Vujanovic, Sebnem Unlu, Toshie Yoneyama, Andrea Vujanovic, Jie Han,Dragic Bankovic,Miroslaw J. Szczepanski,Jennifer L. Hunt, Ronald B. Herberman,
crossref(2023)
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