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个人简介
His laboratory is directed at obtaining a better understanding of factors that regulate synthesis and secretion of hormones that control reproduction, particularly the gonadotropins. Gonadotropin-releasing hormone (GnRH) stimulates synthesis and secretion of gonadotropins by interacting with membrane receptors in the anterior pituitary gland. His research career has focused on understanding the inputs to the pituitary gland that influence the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These studies have ranged from developing analytical techniques to quantify gonadotropin-releasing hormone (GnRH), receptors for GnRH in the pituitary gland, and receptors for estradiol in the pituitary gland and hypothalamus, to evaluating changes in each of these parameters during varying reproductive states in several species including sheep, cattle, horses, dogs, rats and mice. His laboratory has also focused on evaluating the role of membrane estrogen and progesterone receptors in the pituitary gland. He has shown that estradiol has a rapid action to inhibit GnRH-induced secretion of LH, possibly as a mechanism to prevent secretion of LH during the pre-ovulatory period to permit an increase in pituitary content of LH preceding the preovulatory surge. He has also focused on the mechanisms responsible for anestrus and potential methods that may override anestrus.
研究兴趣
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Dan L. Baker,Blake E. McCann,Jenny G. Powers,Nathan L. Galloway,Jason E. Bruemmer, Melissa A. Thompson,Terry M. Nett
Theriogenology Wild (2023): 100061
SSRN Electronic Journal (2022)
Christianne Magee,Jason E Bruemmer, Kelly S Kirkley, Luke A Sylvester, Brittany Runyan,Terry M Nett,Edward L Squires,Colin M Clay
Bioscientifica Proceedings (2019)
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