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个人简介
One of the goals of my lab is to develop new chemical tools to interrogate the interaction between therapeutically relevant proteins. Specific projects in my lab include inhibitors of the estrogen receptor/coactivator interaction and the Keap1/Nrf2 interaction. My unique background in small molecule design, biochemistry, synthetic medicinal chemistry and drug discovery/development is unique among academic scientists of my age. As a Ph.D. student with John Katzenellenbogen, I gained experience with high-throughput screens and developing structure-activity relationships arising from small molecules identified from those screens. As a postdoctoral fellow with Dennis Liotta, I developed an expertise in small molecule hit-to-lead optimization, with a particular emphasis on simultaneously enhancing potency and pharmaceutical properties (e.g., metabolic stability, solubility, plasma stability, etc.) of preclinical agents. Now as an assistant professor in the Department of Medicinal Chemistry and Pharmacognosy, my lab uses the tools of synthetic medicinal chemistry to make probe compounds for targeting proteins relevant in a number of disease states, and in vitro biochemical assays to probe the ability of these molecules to modulate these protein targets.
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