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Cues (conditional stimuli, CSs) that are associated with rewards can act as powerful temptations, leading to maladaptive behavior, such as overeating, or, in the case of drug cues, relapse. However, such cues come to exert powerful control over motivated behavior only if they are attributed with incentive motivational properties (‘incentive salience’). In a series of studies we have found that there is considerable individual variation in the extent to which reward cues acquire incentive motivational properties. Some rats, called sign-trackers (STs) are especially prone to attribute incentive salience to reward cues, relative to others (goal-trackers, GTs). Importantly, the propensity to attribute incentive salience to a food cue also predicts the the propensity to attribute motivational properties to drug cues. That is, STs also have particular difficulty resisting drug cues, in the sense that some classes of drug cues both maintain drug-taking behavior and reinstate drug-seeking behavior to a much greater extent in STs than in GTs. In addition, individual variation in these “bottom-up” motivational processes is associated with individual variation in “top-down” inhibitory control over behavior. Finally, most recently, we have begun to explore the influence of pharmacokinetic factors on the development of addiction-like behavior.
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Christopher P King,Apurva S Chitre,Joel D Leal-Gutiérrez,Jordan A Tripi,Alesa R Hughson,Aidan P Horvath, Alexander C Lamparelli, Anthony George, Connor Martin,Celine L St Pierre, Thiago Sanches,Hannah V Bimschleger,
bioRxiv : the preprint server for biology (2024)
Joel D. Leal-Gutiérrez,Daniel Munro,Denghui Chen,Riyan Cheng,Tengfei Wang,Hao Chen,Paul Meyer,Keita Ishiwari,Terry E. Robinson,Christoph Rau,Michael Garrett
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Cell reportsno. 8 (2023): 112873-112873
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