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职业迁徙
个人简介
Tayyaba Hasan is a Professor of Dermatology at the Wellman Center for Photomedicine, Harvard Medical School (HMS) and a Professor of Health Sciences and Technology (Harvard-MIT). She was the founding Director of the Office for Research Career Development at Massachusetts General Hospital until 2011.
Dr. Hasan's scientific efforts are focused on photochemistry-based approaches (photodynamic therapy, or PDT) for treatment and diagnosis of disease. The overall strategy is to develop molecular mechanisms and optical imaging-based combination treatment regimens where one treatment arm involves light activation of certain near-infrared-absorbing chemicals. This program identifies various cellular and molecular targets for specific diseases and designs constructs for optimal photochemical treatment effects. The targeting entities include photoactivatable nanoparticles and small molecules.
In cancer, the focus malignancies are ovarian, prostate, pancreas and head and neck cancers. In infections and infectious diseases, efforts are targeted toward developing microbial-enzyme-specific photoactivatable molecules for use in PDT. Target organisms in the infectious diseases are leishmaniasis, Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus.
In addition, optimal imaging strategies develop target specific molecular probes for in situ monitoring of cellular processes during treatment such as the up-regulation of vascular endothelial growth factor.
研究兴趣
论文共 750 篇作者统计合作学者相似作者
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Chanda Bhandari, Azophi Moffat,Nimit Shah, Adil Khan, Maxwell Quaye,John Fakhry, Siddharth Soma, Austin Nguyen,Menitte Eroy, Ashritha Malkoochi,Rolf Brekken,Tayyaba Hasan,
PHOTOCHEMISTRY AND PHOTOBIOLOGY (2024)
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2024): 112811-112811
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII (2024)
Barry Liang,Sumiao Pang,Robert Perttila, Chen-Hua Ma,Payal Srivastava,Brandon Gaitan,Aaron Sorrin, Nada Fadul, Idrisa Rahman, Zoe Ylöniemi,Dana Roque,Tayyaba Hasan,
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII (2024)
Mohammad A. Saad, Tessa D. van Bergen, Jimena Nicolás Morala, Harrison J. Roberts, Derek Allen,Zhiming Mai,Tayyaba Hasan
Biophotonics and Immune Responses XIX (2024)
Photochemistry and photobiology (2024)
International journal of molecular sciencesno. 7 (2024): 3811
Shazia Bano, Jose Quilez Alburquerque, Harrison James Roberts,Sumiao Pang,Huang-Chiao Huang,Tayyaba Hasan
Journal of Photochemistry and Photobiology B: Biologypp.112910, (2024)
Sanjay Anand,Alan Shen, Cheng-En Cheng, Jacky Chen,Jennifer Powers,Pat Rayman, Marcela Diaz,Tayyaba Hasan,Edward V Maytin
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