基本信息
浏览量:14
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Professional Interests:
Acyl-Coenzyme A:cholesterol acyltransferase 1(ACAT1) is an enzyme responsible for intracellular cholesterol esterification and storage. It is a membrane bound protein located at the endoplasmic reticulum, and plays important roles in health and in diseases. Our laboratory identified the ACAT1 gene. We are conducting structure- function analysis of ACAT1 in vitro, and taking mouse genetic approaches to determine the pathophysiological role of ACAT1 in Alzheimer’s disease, in atherosclerosis, and in diet-induced obesity. In addition, this lab has been involved in using mutant cell lines to dissect discrete steps in intracellular cholesterol trafficking.
Acyl-Coenzyme A:cholesterol acyltransferase 1(ACAT1) is an enzyme responsible for intracellular cholesterol esterification and storage. It is a membrane bound protein located at the endoplasmic reticulum, and plays important roles in health and in diseases. Our laboratory identified the ACAT1 gene. We are conducting structure- function analysis of ACAT1 in vitro, and taking mouse genetic approaches to determine the pathophysiological role of ACAT1 in Alzheimer’s disease, in atherosclerosis, and in diet-induced obesity. In addition, this lab has been involved in using mutant cell lines to dissect discrete steps in intracellular cholesterol trafficking.
研究兴趣
论文共 252 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
International Journal of Molecular Sciencesno. 6 (2023): 5616-5616
Adrianna L. De La Torre, Caleb Smith,Joseph Granger,Faith L. Anderson, Taylor C. Harned,Matthew C. Havrda,Catherine C.Y. Chang,Ta-Yuan Chang
Journal of Neuroscience Methods (2022): 109437
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 6 (2022)
Maximillian A. Rogers,Catherine C. Y. Chang,Robert A. Maue,Elaina M. Melton,Andrew A. Peden,William S. Garver, Junghoon Lee,Peter Schroen, Mitchell Huang,Ta-Yuan Chang
Proceedings of the National Academy of Sciencesno. 18 (2022)
Ta Yuan Chang, Catherine C Y Chang, Taylor C Harned,Adrianna L De La Torre, Junghoon Lee,Thao N Huynh,James G Gow
Exploration of neuroprotective therapyno. 3 (2021): 173-184
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn