基本信息
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Bio
The major objective of my research program is to fully integrate the mechanistic studies performed at the molecular and cellular levels with complex in vivo models of human diseases to yield a complete understanding of fundamental problems in physiology and pathophysiology. The major research focus of the lab is on the mechanisms governing the pathological and adaptive vasculature development, neoangiogenesis, in adult organisms. This process is crucial for the tissue recovery from ischemia, a response that is triggered in a variety of pathogenic settings including the complications of thrombosis, injury and wound healing, and cancer progression and tumor metastatic spread. At the cellular level, we are interested in endothelial cell biology, therole of inflammatory and other blood cells, including platelets, during neovascularization. To consider neoangiogenesis at a molecular level, my research has emphasized the regulatory functions of extracellular matrix, its cellular receptors, integrins and signaling pathways and the interrelationship between these processes. For our angiogenesis studies, we employ cutting edge animal models, including angiogenesis induced by various tumors, by ischemic conditions in hind limbs, wounds and skin transplants, and by gene transfer of the growth factor of interest. We have established a number of other valuable in vivo models that include wound healing, tumor progression, metastasis and tumor-induced bone remodeling intransgenic/knockout mice, angiogenesis and blood flow analysis, atherosclerosis and thrombosis models.
Research Interests
Papers共 255 篇Author StatisticsCo-AuthorSimilar Experts
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Luyang Xiong,Irina Zhevlakova,Xiaoxia Z West,Detao Gao,Rakhilya Murtazina, Anthony J Horak,Jonathan Mark Brown, Iuliia Molokotina,Eugene Podrez,Tatiana V Byzova
crossref(2024)
Junchul Shin, Junyoung Hong,Jonnelle Edwards-Glenn,Irene Krukovets,Svyatoslav Tkachenko,Maria L. Adelus,Casey E. Romanoski,Sanjay Rajagopalan,Eugene Podrez,Tatiana V. Byzova, Olga Stenina-Adongravi,Olga A. Cherepanova
Luyang Xiong,Irina Zhevlakova,Xiaoxia Z. West,Detao Gao, Rakhylia Murtazina,Anthony Horak,J. Mark Brown, Iuliia Molokotina,Eugene A. Podrez,Tatiana V. Byzova
eLife (2023)
The Journal of investigative dermatologyno. 11 (2022): 3082-+
Tejasvi Dudiki,Daniel W Nascimento, Lauren S Childs, Swetha Kareti,Charlie Androjna,Irina Zhevlakova,Tatiana V Byzova
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Author Statistics
#Papers: 251
#Citation: 11827
H-Index: 56
G-Index: 105
Sociability: 6
Diversity: 3
Activity: 58
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