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The research in the laboratory is focused on investigation of how gene expression and chromatin structure is regulated by the epigenetic mechanisms. Specifically, we are interested in how histone variants influence chromatin states and transcription. Dr Soboleva has recently discovered a novel histone variant in mice, H2A.Lap1. We have found that mice have a family of four H2A.Lap1-like variants, all related to a human variant, H2A.Bbd. The detailed in-depth study of the function of H2A.Lap1 variant in vivo, showed that this histone protein alters chromatin structure to allow activation of genes during specific stages of spermatogenesis. In addition, we found that in the testis, H2A.Lap1 interacts with the RNA splicing machinery – a very unexpected and novel observation, never previously reported for histone variants. These results provide new avenues for a number of exciting research projects for PhD students and Honours students.
The research in the laboratory is focused on investigation of how gene expression and chromatin structure is regulated by the epigenetic mechanisms. Specifically, we are interested in how histone variants influence chromatin states and transcription. Dr Soboleva has recently discovered a novel histone variant in mice, H2A.Lap1. We have found that mice have a family of four H2A.Lap1-like variants, all related to a human variant, H2A.Bbd. The detailed in-depth study of the function of H2A.Lap1 variant in vivo, showed that this histone protein alters chromatin structure to allow activation of genes during specific stages of spermatogenesis. In addition, we found that in the testis, H2A.Lap1 interacts with the RNA splicing machinery – a very unexpected and novel observation, never previously reported for histone variants. These results provide new avenues for a number of exciting research projects for PhD students and Honours students.
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论文共 17 篇作者统计合作学者相似作者
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CELLSno. 4 (2020): 867
Charlotte Moretti, Maria-Elisabetta Serrentino,Côme Ialy-Radio,Marion Delessard,Tatiana A Soboleva,Frederic Tores,Marjorie Leduc,Patrick Nitschké,Joel R Drevet,David J Tremethick,Daniel Vaiman,Ayhan Kocer,
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