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个人简介
I am a neurobiologist with >15 years of research experience in combining in vivo behavioural models of neurodegeneration and ex vitro molecular approaches to facilitate cell- and pathway-specific mechanistic knowledge. As a PI or co-investigator and a research scientist on several NIH, TRDRP and NIAA-funded projects, I laid the groundwork for the experiments on opto- and chemogenetic manipulation of neural circuits in behaving mice. These studies have enabled precise manipulation of translationally relevant (patho)physiological pathways and cellular mechanisms in rodent and non-human primate (NHP) models of Parkinson’s disease (PD), L-dopa-induced dyskinesias (LIDs), nicotine-dependence associated somatic withdrawal signs and model of alcohol use disorder. My early research to find translationally relevant molecular targets for neuroprotection in PD (Bordia et al., 2008, 2010) shows that nicotinic receptor agonist treatment restored dopaminergic markers and decreased LIDs in rodents and NHP models without compromising the antiparkinsonian effect of L-dopa. These studies outlined the funded proposal to investigate the enhanced striatal cholinergic signaling in LIDs expression and resulted in two research papers (Bordia et al., 2016, Perez et al., 2017) and a review. The TRDRP-funded research to investigate nicotine-mediated dopaminergic activity in ventral tegmental responsible for smoking relapse revealed a target responsible for nicotine dependence and withdrawal associated somatic signs that could be leveraged for smoking cessation. My recent preliminary work showed a role for sphingosine agonism-in reducing motor deficits in transgenic mice overexpressing the human α-synuclein with a PD-associated mutation in A53T gene. Over the course of my career, I have successfully managed several projects, as well as trained and supervised staff. I have published peer-reviewed papers and reviews based on these projects which have involved collaborations with researchers.
研究兴趣
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JOURNAL OF NEUROCHEMISTRY (2017): 199-199
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