She is a urologic pathologist and physician-scientist whose laboratory studies tissue-based predictive and prognostic biomarkers in prostate cancer. The group has a particular interest in the molecular contributors to prostate cancer health disparities. Her group also studies mTOR signaling and its role in tumorigenesis, with a focus on renal oncogenesis.

Dr. Lotan is engaged in research training and is the co-PI of the OPTIC T32 in pathology, enabling pathology residents to engage in 2-3 years of laboratory research. She is currently the Deputy Director for Research Affairs in the Department of Pathology.