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个人简介
Tamas Freund has been involved for over 30 years in functional anatomical studies on cortical microcircuits, employing combinations of immunocytochemistry, electron micorscopy, in vitro and in vivo electrophysiology. His conceptually novel research uncovered: 1) new molecular pathways in the communication of nerve cells, 2) the identity and principles of connectivity of neurons that build up cortical circuitry, and 3) the generation of network activity patterns that underlie various stages of information processing and storage in the brain. He made significant discoveries regarding the structure and function of cortical microcircuits, with particular attention to their inhibitory components, and relationship to oscillations that underlie different stages of memory formation. He discovered that pacemaker neurons in the septal region are GABAergic, inhibitory, and selectively innervate GABAergic interneurons in the hippocampus, thereby synchronizing activity rhythmically at theta frequency. His results in the epilepsy field provided direct evidence for an early loss of inhibitory interneurons. His group discovered that CB1 cannabinoid receptors inhibit neurotransmitter release, and described the structure and operational principles of this circuit breaker in several brain regions. Even though his work is mostly considered basic research in the field of biomedical sciences, his results have considerable relevance to pharmaceutical and clinical research.
研究兴趣
论文共 171 篇作者统计合作学者相似作者
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Armando Romani,Alberto Antonietti, Davide Bella, Julian Budd, Elisabetta Giacalone, Kerem Kurban,Sara Saray,Marwan Abdellah,Alexis Arnaudon, Elvis Boci, Cristina Colangelo,Jean-Denis Courcol,
bioRxiv (Cold Spring Harbor Laboratory) (2024)
György Buzsáki,Tamás Freund, Desdemona Fricker, Attila I Gulyás,Gilles Huberfeld, Liset Menendez de la Prida,Jean Christophe Poncer,Katalin Tóth,Roger Traub,Lucia Wittner,Robert K S Wong
The Journal of physiology (2024)
Áron Orosz,Virág Takács,Zsuzsanna Bardócszi,Ábel Major, Luca Tar,Péter Berki,Péter Papp,Márton Mayer, Luca Zsolt,Katalin Sos,Szabolcs Káli,Tamás Freund,
IBRO Neuroscience Reports (2023): S326-S326
Virag Takacs,Peter Papp,Aron Orosz,Zsuzsanna Bardoczi, Tamas Zsoldos,Masahiko Watanabe,Zsofia Magloczky, Peter Gombas,Tamás F. Freund,Gabor Nyiri
biorxiv(2023)
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Nature Communicationsno. 1 (2023): 7584-7584
biorxiv(2020)
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