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We are interested in how early-life experience (specifically stress or seizures) influence the function of brain cells persistently (‘re-program’ them), to result in human disease. We aim to understand the mechanisms of this neuroplasticity and employ the information to design therapies for prevention/treatment of stress-related disorders and epilepsy, respectively. Lab members use animal models and in vitro systems including slice cultures and dissociated neurons to study: (a) how seizures induce large-scale, epigenetic changes in gene transcription programs in neurons, including expression of ion channels; how ion channels are trafficked in neurons and how this trafficking is altered by seizures; and how inflammatory mediators contribute to the process by which the brain becomes epileptic after long febrile seizures. Students use use cutting edge methods in molecular biology (ChIP), live imaging of genetically manipulated neurons, and high resolution (11T ) in vivo imaging. (b) how early life stress or enriched experience modify gene expression and synaptic function in the hippocampus and in specific hypothalamic neurons, predisposing to- or protecting from-cognitive decline and stress-related disorders. Students use genetically modified mice where hippocampal neurons are visible to examine in real time how stress and hormones influence dendritic spine dynamics and neuronal structure. They test how these changes influence learning and memory. Mechanisms of experience- induced changes in neuronal gene expression (programming) are studied using neuroanatomical, molecular biology and physiological approaches. Lab members collaborate extensively, and publish in outstanding journals.
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Cassandra L Kooiker,Matthew T Birnie, Amalia Floriou-servou, Qinxin Ding, Neeraj Thiagarajan, Mason Hardy,Tallie Z Baram
crossref(2024)
Journal of affective disorders (2024): 281-287
JOURNAL OF AFFECTIVE DISORDERS (2024): 281-287
eneuropp.ENEURO.0006-24.2024, (2024)
Febrile Seizurespp.195-217, (2023)
Febrile Seizurespp.341-344, (2023)
Biological Psychiatry Global Open Scienceno. 1 (2023): 99-109
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