基本信息
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The Begley Group is interested in the mechanistic chemistry and enzymology of complex organic transformations, particularly those found on the vitamin biosynthetic pathways. We are currently working on the biosynthesis of thiamin, molybdopterin, pyridoxal phosphate and menaquinone. Our research involves a combination of molecular biology, protein biochemistry, organic synthesis and structural studies and provides a strong training for students interested in understanding the organic chemistry of living systems and in pursuing careers in biotechnology, drug design or academia.
Thiamin pyrophosphate plays a key role in the stabilization of the acyl carbanion synthon in carbohydrate and amino acid metabolism. The biosyntheses of the thiamin pyrimidine and thiazole are complex and are different from any of the characterized chemical or biochemical routes to these heterocycles.
Research Interests
Papers共 391 篇Author StatisticsCo-AuthorSimilar Experts
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ACS central scienceno. 5 (2024): 988-1000
Journal of Biological Chemistryno. 3 (2024)
Sohan Hazra,Tadhg Begley
Journal of Biological Chemistryno. 3 (2024)
ACS Central Scienceno. 5 (2024): 988-1000
Sreyashi Sinha, Saad Naseem, Sanjoy Adak, Xiaohong Jian, Jessica Steiner, Aarthy Thiagaraya Selvam, Dymtro Fedoseyenko,Tadhg Begley
Journal of Biological Chemistryno. 3 (2024)
Journal of the American Chemical Societyno. 22 (2023): 11933-11938
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