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Research in the Scammell Lab focuses on the neurobiology of sleep and the neural basis of narcolepsy. Narcolepsy is caused by an extensive and selective loss of the hypothalamic neurons that produce the orexin neuropeptides (also known as hypocretins). This cell loss generally occurs in the teens or young adulthood and results in lifelong sleepiness and cataplexy, brief episodes of muscle weakness that are similar to the paralysis that occurs during REM sleep. Much of our current work focuses on mouse models of narcolepsy because mice lacking orexins also have sleepiness and frequent episodes of cataplexy. We hypothesize that orexins normally stabilize the activity of wake-promoting brain regions, but absence of orexins produces behavioral state instability, with rapid transitions from wakefulness into sleep, and intrusions into wakefulness of REM sleep elements such as cataplexy or hallucinations.
Research Interests
Papers共 244 篇Author StatisticsCo-AuthorSimilar Experts
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Tobias Di Marco,Ina Djonlagic,Yves Dauvilliers,Kolia Sadeghi, David Little,Alexandre N. Datta, Jeffrey Hubbard,Goeran Hajak,Andrew Krystal,Antonio Olivieri,Liborio Parrino, Corey B. Puryear,
Tobias Di Marco,Thomas E Scammell,Kolia Sadeghi,Alexandre N Datta, David Little, Nurkurniati Tjiptarto,Ina Djonlagic,Antonio Olivieri,Gary Zammit,Andrew Krystal,Jay Pathmanathan,Jacob Donoghue,
Journal of sleep researchpp.e14256-e14256, (2024)
T. Di Marco,I. Djonlagic,Y. Dauvilliers, N. Tjiptarto, A. Arslan, A. Datta, G. Hajak, J. Hubbard, D. Kleinschmidt,A. Krystal, D. Little, A. Olivieri,
Sleep Medicine (2024): 172-173
Sleep Medicine (2024): 213
biorxiv(2024)
Sleep (2024)
bioRxiv : the preprint server for biology (2024)
Chloe Alexandre,Giulia Miracca, Victor Duarte Holanda, Ashley Sharma, Kamila Kourbanova,Ashley Ferreira,Maira A. Bicca, Xiangsunze Zeng, Victoria A. Nassar,Seungkyu Lee,Satvinder Kaur,Sridevi V. Sarma,
SCIENCE TRANSLATIONAL MEDICINEno. 743 (2024): eadg3036-eadg3036
SLEEPno. Supplement_1 (2023): A263-A263
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Author Statistics
#Papers: 247
#Citation: 25934
H-Index: 69
G-Index: 161
Sociability: 8
Diversity: 3
Activity: 59
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