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Bio
Clinical
My clinical research interests are in the pre-clinical and clinical development of novel anti-cancer agents including molecular targeted therapies and gene therapy. I run a number of Phase 1 clinical trials of innovative anti-cancer agents, and I also run the Analytical Services Unit at the Centre for Oncology and Applied Pharmacology, University of Glasgow. My clinical research interests also include the development of novel therapies for gastro-oesophageal and hepato-biliary-pancreatic cancers and melanoma.
Laboratory
Current strategies in the development of novel therapies are based on exploiting our increasing understanding of the molecular basis of cancer. The classical paradigm for developing cancer therapeutics is dependent on demonstrating a reduction in tumour size on serial clinical or radiological assessments as an indication of anti-tumour activity. However tumour volume is a complex integral of growth, involution, necrosis and inflammatory processes, and so volume alone is not the most appropriate parameter in determining response. Coupled with this, the current generation of molecular-targeted therapies have been designed to inhibit specific molecular processes and may not consistently result in objective tumour reduction in patients with advanced refractory tumours despite producing their desired biological effect. My group is attempting to overcome this problem by developing novel laboratory models that allows us to determine how potentially anti-invasive agents might best be evaluated in subsequent clinical trials, and by developing bio-markers of anti-tumour activity to specific agents that can be applied to biological samples collected from patients in clinical trials of novel anti-cancer agents
Research Interests
Papers共 477 篇Author StatisticsCo-AuthorSimilar Experts
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Liver Cancer (2024)
Pavlina Spiliopoulou,Farasat Kazmi,Francesca Aroldi, Thomas Holmes, David Thompson, Lucinda Griffiths,Cathy Qi,Matthew Parkes,Simon Lord,Gareth J. Veal, David J. Harrison,Vicky M. Coyle,
Journal of Experimental & Clinical Cancer Researchno. 1 (2024): 1-16
Cancer Researchno. 6_Supplement (2024): 6222-6222
Cancer Researchno. 6_Supplement (2024): 5650-5650
European Journal of Cancer (2024): 114009-114009
Fieke E. M. Froeling,Juan Valle,Rosie Upstill-Goddard, Paul Grimwood,Paul Westwood,Stephan B. Dreyer,Caroline Kelly,Fraser Duthie, Judith Dixon, Sarah Bradley,T. R. Jeffry Evans,Owen J. Sansom,
CANCER RESEARCHno. 2 (2024)
Brooke A Pereira,Shona Ritchie,Cecilia R Chambers, Katie A Gordon,Astrid Magenau,Kendelle J Murphy,Max Nobis, Victoria M Tyma, Ying Fei Liew,Morghan C Lucas,Marjan M Naeini, Deborah S Barkauskas,
Science advancesno. 27 (2024): eadl1197-eadl1197
H.S. Wasan, J. Wang, E.M. Elaine McCartney,H. Soifer,K. Treuner, Y. Zhang, C. Schnabel, K. Carty, L. McMahon,T.R.J. Evans, M.C. Nicolson, H. Thygesen,
Annals of Oncology (2023): S1339-S1339
crossref(2023)
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