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个人简介
I graduated from Okayama University Medical School in 1992, and after obtaining a medical license, I started a career of scientist. My research interest has been focusing on the application of basic research to clinical applications especially in oncology. I have been conducting the proteomic study since 1992, and the cancer biomarker development since 2001. Proteomics is the functional translation of genome, and the cancer proteomics is one of the most promising approaches for the biomarker discovery. I crated a protein expression analysis system using large format two-dimensional difference gel electrophoresis (Kondo et al 2007 Nat Protocols), and used it for the study on clinical materials such as surgical specimens. By examining thousands of tumor tissues, which were stratified based on the clinical and pathological data, I found a number of intriguing proteins, which could be candidates of biomarkers. Among many malignancies examined, I became to have more interest in the rare cancers such as sarcomas. To investigate the molecular backgrounds of identified biomarker proteins and promote the biomarker studies, I started to establish the patient-derived cancer models since 2014. I found that the difficulty of conducting rare cancer research is partly attributable to a lack of adequate patient-derived cancer models. Since then, I examined more than 300 rare cancer cases, and established the patient-derived cancer models from approximately 100 cases. The established models have been delivered to the researchers and pharmaceutical companies for both basic and translational research. The medical seeds and research resources that I have been creating will lead a novel discovery in basic research and innovative therapeutic applications, which will be appreciated by the patients and their family in the future generations.
研究兴趣
论文共 487 篇作者统计合作学者相似作者
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Cancer scienceno. 5 (2024): 1378-1387
Human Cellno. 3 (2024): 1-9
Human cell (2024)
Julia Osaki,Rei Noguchi,Takuya Ono, Yuki Adachi, Shuhei Iwata,Yu Toda, Takaya Funada,Shintaro Iwata,Naoki Kojima,Akihiko Yoshida,Akira Kawai,Tadashi Kondo
Human Cellpp.1-8, (2024)
Oncology lettersno. 2 (2024): 381-381
Human cellno. 3 (2024): 854-864
Kyra Parker, Yanfeng Zhang, Gavin Anchondo, Ashlyn Smith, Sergio Guerrero Pacheco,Tadashi Kondo,Le Su
Frontiers in Cell and Developmental Biology (2024)
Research Square (Research Square)no. 3 (2024): 1-12
Human Cellno. 1 (2023): 337-344
CANCER SCIENCE (2023): 794-794
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作者统计
#Papers: 485
#Citation: 7268
H-Index: 41
G-Index: 62
Sociability: 7
Diversity: 4
Activity: 101
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