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Lipids are building blocks for membranes and their regulated production during development often underlies striking morphological changes in a variety of specialized cell types. In addition, lipids act as signals by which organelles and cells communicate with each other and as energy storage molecules. Defects in lipid metabolism or signalling can lead to a large number of disorders such as metabolic syndrome or cancer.
The aim of our laboratory is to understand how cells maintain lipid and membrane homeostasis during growth and development. Our current studies focus on a fundamental step in lipid metabolism, the dephosphorylation of phosphatidic acid (PA) to diacylglycerol (DAG), which is catalysed by a conserved family of lipid phosphatases, lipins. DAG generated by lipins is used for the biosynthesis of (a) membrane phospholipids and (b) triglyceride stored in lipid droplets. Consistent with these essential metabolic functions, lipins are important regulators of both organelle biogenesis and fat storage in many eukaryotic cells.
Lipids are building blocks for membranes and their regulated production during development often underlies striking morphological changes in a variety of specialized cell types. In addition, lipids act as signals by which organelles and cells communicate with each other and as energy storage molecules. Defects in lipid metabolism or signalling can lead to a large number of disorders such as metabolic syndrome or cancer.
The aim of our laboratory is to understand how cells maintain lipid and membrane homeostasis during growth and development. Our current studies focus on a fundamental step in lipid metabolism, the dephosphorylation of phosphatidic acid (PA) to diacylglycerol (DAG), which is catalysed by a conserved family of lipid phosphatases, lipins. DAG generated by lipins is used for the biosynthesis of (a) membrane phospholipids and (b) triglyceride stored in lipid droplets. Consistent with these essential metabolic functions, lipins are important regulators of both organelle biogenesis and fat storage in many eukaryotic cells.
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Papers共 47 篇Author StatisticsCo-AuthorSimilar Experts
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The Journal of cell biologyno. 8 (2023)
FEBS lettersno. 10 (2023): 1226-1234
Emily R Rowe,Michael L Mimmack,Antonio D Barbosa,Afreen Haider, Iona Isaac,Myriam M Ouberai, Abdou Rachid Thiam,Satish Patel,Vladimir Saudek,Symeon Siniossoglou, David B Savage
Cellsno. 24 (2022): 4120-4120
PLoS ONEno. 7 (2020): e0235746
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