Transplantation of cells, tissues and organs has been identified by the World Health Organisation as an important global therapeutic approach. It has improved patients’ lives and extended the lifespan of many hundreds of thousands of individuals worldwide. The use of stem cells and their products may therefore lead to novel cell and molecular therapies for a wide variety of medical conditions, including haematological malignancies, wound repair and cardiovascular disease. The Stem Cell Research Laboratory research programme aims to understand the biology of stem cell development, stem cell decision making and the homing/engraftment of stem cells into tissues, with the objective of translating this research into the clinic. As stem cells and their progeny play a pivotal role in regulating blood and blood vessel formation, our particular studies concentrate on the role of haemopoietic and vascular stem cells and their progeny in blood and blood vessel regeneration. We use the bone marrow, cardiovascular system and skin as tissue exemplars.