Suzanne Leal
教授
Gertrude H. Sergievsky Center;Center for Statistical Genetics
Baylor College of Medicine;Columbia University in the City of New York;Department of Neurology, Irving Medical Center, Columbia University;The Neurological Institute of New York, Irving Medical Center, Columbia University
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基本信息
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个人简介
My primary interest lies in understanding the genetic etiology of complex and Mendelian traits, with an emphasis on developing and applying statistical and epidemiological methods to tackle these complex problems. I have worked extensively on method and software development to aid in gene identification and elucidating the genetics of disease etiology. One of my interests is developing methods to analyze rare variants obtained from sequence data, including methods to analyze family data, detect epistasis, and pleiotropy. My publication on the combined multivariate collapsing (CMC) method was the first article to describe a rare-variant aggregate test to detect complex disease associations. I have also developed additional methods to identify associations with rare variants with application to population- and family-based sequence data. Rare-variant aggregate methods were also developed to perform parametric and non-parametric linkage analysis. Additionally, methods were developed to estimate the effect sizes for rare variants; simulate rare variants to compare methods and estimate power and type I error; and estimate sample sizes for complex and Mendelian traits.
研究兴趣
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Brain communicationsno. 3 (2024): fcae142-fcae142
Brain Communications (2024)
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European Journal of Human Geneticsno. 12 (2023): 1447-1454
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Dong-Chuan Guo,Xueyan Duan, Kathleen Mimnagh,Alana C Cecchi,Isabella C Marin, Yang Yu, Walter V Velasco,Kwanghyuk Lee, Xue Zhu,David R Murdock,Suzanne M Leal,Marsha M Wheeler,
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