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The laboratory is focused on elucidating the mechanisms driving diffuse high-grade glioma (HGG) in children. In children and adults, diffuse high-grade gliomas (HGGs), including Grade III anaplastic astrocytomas and Grade IV glioblastomas, share a devastating outcome, with median survival slightly greater than one year, and five-year survival of 10-25%. Although HGGs from different age groups share related gene expression signatures, histopathological features, and frequent mutations in common pathways, there are a number of distinguishing features of pediatric HGG that indicate a unique pathogenesis. While adult glioblastomas arise predominantly in the cerebral cortex, in children, a broader spectrum of anatomical locations are more frequently involved, including the occurrence of diffuse intrinsic pontine gliomas (DIPGs), which arise in the brainstem.
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Molecular cancerno. 1 (2024): 123-123
ALZHEIMERS & DEMENTIAno. 4 (2024): 2526-2537
Marisa Denkinger,Suzanne Baker,Ben Inglis, Sarah Kobayashi, Alexis Juarez, Suzanne Mason,William Jagust
PLOS ONE (2024)
Frontiers in Neuroimaging (2024)
Frontiers in Neuroimaging (2024)
Frontiers in neuroimaging (2024): 1355402-1355402
Alzheimer's & dementia : the journal of the Alzheimer's Associationno. 3 (2024): 2113-2127
bioRxiv : the preprint server for biology (2023)
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