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The laboratory is focused on elucidating the mechanisms driving diffuse high-grade glioma (HGG) in children. In children and adults, diffuse high-grade gliomas (HGGs), including Grade III anaplastic astrocytomas and Grade IV glioblastomas, share a devastating outcome, with median survival slightly greater than one year, and five-year survival of 10-25%. Although HGGs from different age groups share related gene expression signatures, histopathological features, and frequent mutations in common pathways, there are a number of distinguishing features of pediatric HGG that indicate a unique pathogenesis. While adult glioblastomas arise predominantly in the cerebral cortex, in children, a broader spectrum of anatomical locations are more frequently involved, including the occurrence of diffuse intrinsic pontine gliomas (DIPGs), which arise in the brainstem.
Research Interests
Papers共 423 篇Author StatisticsCo-AuthorSimilar Experts
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Molecular cancerno. 1 (2024)
Alzheimer's & dementia : the journal of the Alzheimer's Associationno. 4 (2024): 2526-2537
Marisa Denkinger,Suzanne Baker,Ben Inglis, Sarah Kobayashi, Alexis Juarez, Suzanne Mason,William Jagust
PloS oneno. 6 (2024): e0299764-e0299764
Antoine Leuzy, Lars Lau Raket,Victor L Villemagne,Gregory Klein,Matteo Tonietto, Emily Olafson,Suzanne Baker, Ziad S Saad,Santiago Bullich,Brian Lopresti, Sandra Sanabria Bohorquez,Mercè Boada,
Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Frontiers in Neuroimaging (2024): 1355402-1355402
Alzheimer's & dementiano. 3 (2024): 2113-2127
bioRxiv : the preprint server for biology (2023)
The Journal of nuclear medicineno. 12 (2023): 1980-1989
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Author Statistics
#Papers: 412
#Citation: 30861
H-Index: 82
G-Index: 175
Sociability: 8
Diversity: 3
Activity: 230
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