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Research Interests
Our lab goal is to understand glial function at the animal, cell, and molecular level in order to elucidate mechanisms of normal development and disease progression.
The main research focus includes:
The role of Golgi outposts in acentrosomal microtubule nucleation in oligodendrocytes. Our lab is investigating partner proteins that work in concert with the microtubule nucleator TPPP to organize microtubules. In addition, we are making important observations on the biophysical properties of TPPP and how this can lead to aggregation in neurodegenerative diseases.
Mechanisms of mRNA transport in oligodendrocytes. Our lab is using mouse models to understand the importance of mRNA transport in in vivo myelination. We are also using biochemical and biophysical techniques to identify the molecular players involved in these transport processes.
Our lab goal is to understand glial function at the animal, cell, and molecular level in order to elucidate mechanisms of normal development and disease progression.
The main research focus includes:
The role of Golgi outposts in acentrosomal microtubule nucleation in oligodendrocytes. Our lab is investigating partner proteins that work in concert with the microtubule nucleator TPPP to organize microtubules. In addition, we are making important observations on the biophysical properties of TPPP and how this can lead to aggregation in neurodegenerative diseases.
Mechanisms of mRNA transport in oligodendrocytes. Our lab is using mouse models to understand the importance of mRNA transport in in vivo myelination. We are also using biochemical and biophysical techniques to identify the molecular players involved in these transport processes.
研究兴趣
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Shahrnaz Kemal, Hunter S. Richardson,Thomas S. McAlear,Andrii Kopach, Joseph C. Nowacki, Yan Li,Susanne Bechstedt,Meng-meng Fu
MOLECULAR BIOLOGY OF THE CELLno. 2 (2023): 658-658
Proceedings of the National Academy of Sciences of the United States of America (2019)
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