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3D cultures of sarcoma cells, mimicking patient-relevant treatment schedules; assessment by high throughput assays but also by histology and protein – and RNA expression as well as DNA damage response per immunofluorescence and western blot studies.
Chemosensitisation and radiosensitisation of sarcoma cell models.
Identification of effective combination therapies at clinically relevant doses with focus on strategies involving DNA repair inhibitors.
Tumour sample/ molecular profiling related research linked to clinical trials and outcome data; most recent ongoing analysis is in relationship to the ongoing arm D in ESMART (olaparib/ irinotecan) with the aim to identify biomarkers for response to this combination.
Chemosensitisation and radiosensitisation of sarcoma cell models.
Identification of effective combination therapies at clinically relevant doses with focus on strategies involving DNA repair inhibitors.
Tumour sample/ molecular profiling related research linked to clinical trials and outcome data; most recent ongoing analysis is in relationship to the ongoing arm D in ESMART (olaparib/ irinotecan) with the aim to identify biomarkers for response to this combination.
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论文共 27 篇作者统计合作学者相似作者
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Silvia Pomella,Matteo Cassandri, Lucrezia D'Archivio,Antonella Porrazzo,Cristina Cossetti,Doris Phelps,Clara Perrone,Michele Pezzella,Antonella Cardinale,Marco Wachtel, Sara Aloisi,David Milewski,
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Cancer Researchno. 8_Supplement (2023): CT087-CT087
Susanne A. Gatz, Anne C. Harttrampf,Caroline Brard,Francisco J. Bautista,Nicolas Andre,Samuel Abbou,Jonathan Rubino,Windy Rondof,Marc Deloger, Marc Rubsam,Daniel Hubschmann,Lynley V. Marshall,
CANCER RESEARCHno. 8 (2023)
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Andrew D J Pearson,Sara Federico,Susanne A Gatz,Michael Ortiz,Giovanni Lesa,Nicole Scobie, Ioannis Gounaris,Susan L Weiner,Brenda Weigel, T J Unger,Elizabeth Stewart,Malcolm Smith,
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Cancer Researchno. 8_Supplement (2023): CT088-CT088
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Cancer Researchno. 8_Supplement (2023): CT019-CT019
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