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The main focus of our lab is to understand how cells detect and repair DNA damage induced by ionizing radiation and chemotherapeutic drugs. Of particular interest are the roles of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Ataxia Telangiectasia Mutated (ATM) in the cellular response to DNA damage. A major goal is to use our knowledge of the DNA damage response to develop novel approaches to improve cancer treatment. We are currently exploring the use of poly ADP ribose polymerase (PARP) inhibitors to target ATM deficient cancers and the role of PI3 kinase in cisplatin resistance.
Research Interests
Papers共 246 篇Author StatisticsCo-AuthorSimilar Experts
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Nature communicationsno. 1 (2024): 2200-2200
NATURE COMMUNICATIONSno. 1 (2024)
Nature Communicationsno. 1 (2024): 1-1
Nature communicationsno. 1 (2024): 2836-2836
Biochemical Society transactions (2023)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
Biophysical journalno. 3S1 (2023): 150a-150A
Science Advancesno. 22 (2023): eadg2838-eadg2838
Eli S. Williams,Rebekah Klingler, Brian Ponnaiya, Tanja Hardt,Evelin Schrock,Susan P. Lees-Miller,Katheryn Meek,Robert L. Ullrich,Susan M. Bailey
crossref(2023)
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