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Her laboratory initially studied the role of ammonium transport along the collecting duct and its role in the renal regulation of acid-base balance. More recently, her research involves the study renal Cl-transporters and their role in the regulation of blood pressure.
Dr. Wall’s laboratory has made major contributions to our understanding of the renal regulation of net acid secretion and blood pressure. They were the first to characterize direct, transepithelial transport of ammonium (NH4+) along the collecting duct. Previously it was believed that NH4+ secretion along the collecting duct occurs exclusively through active H+ secretion in parallel with the nonionic diffusion of NH3. Wall and colleagues observed direct NH4+ transport along the collecting duct, mediated by the Na,K-ATPase. She observed that Na,K-ATPase-mediated NH4+ uptake represents 50% of net acid secreted along the terminal inner medullary collecting duct during hypokalemia, which contributes to the metabolic alkalosis observed in this treatment model. Because NH4+ is the major regulatable component of net acid secretion, these observations provide an important and novel mechanism for the renal regulation of net acid secretion.
More recently, Dr. Wall has studied the contribution of renal Cl-transporters to the maintenance of vascular volume, blood pressure and acid-base balance. She and her colleagues have localized the Cl-/HCO3- exchanger pendrin (Slc26a4) to the apical region of subpopulations of intercalated cells within the distal nephron. Pendrin, she observed, is upregulated following aldosterone, primarily by changing the subcellular distribution of pendrin from the subapical space to the apical plasma membrane. Pendrin mediates HCO3- secretion and Cl- absorption, which reduces arterial pH and expands vascular volume, thereby increasing blood pressure. The Wall Laboratory first described the novel role of pendrin in blood pressure regulation. Pendrin plays an important role in the hypertensive response to aldosterone by increasing the renal absorption of Cl-.
Dr. Wall attends on the renal consult service at Emory University Hospital. Her main clinical interests are in the pathophysiology of acid-base and blood pressure regulation. She is also interested in the removal of drugs through dialysis.
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Hyun Jun Jung,Truyen D Pham,Xiao-Tong Su, Teodora Veronica Grigore, Joost G Hoenderop,Hannes Olauson,Susan M Wall,David H Ellison,Paul A Welling,Lama Al-Qusairi
Scientific reportsno. 1 (2024): 10740-10740
JOURNAL OF HYPERTENSION (2023): E379-E379
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PHYSIOLOGYno. S1 (2023)
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American journal of physiology. Cell physiologyno. 5 (2023): C1171-C1178
American journal of physiology. Renal physiologyno. 2 (2023): F202-F218
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGYno. 3 (2023): F377-F393
Pflugers Archiv : European journal of physiologyno. 5 (2023): 607-620
Cesar A Romero, Jasmine Lim,Hong Wang, Brandi M Wynne, Peipei Ma,Yao Jing,Dennis C Liotta,Michael D'Erasmo,Stephen F Traynelis,Douglas C Eaton,Susan M Wall
bioRxiv : the preprint server for biology (2023)
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