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Bio
My research seeks to use structural information to understand molecular mechanisms involved in human health and disease states.
Projects focus on different biological systems ranging from bacterial pathogenesis systems to systems involved in human cell division. A common theme is how large, multiprotein, often membrane-crossing, complexes are assembled.
The studies of bacterial pathogenesis often examine large membrane-spanning complexes involved in bacterial protein/toxin secretion or bacterial movement. Research on human systems includes studies of serum-resident protein cascades involved in immune responses and coagulation, how centrosomes assemble during mitosis and how a variety of integral membrane proteins function in protein and membrane maturation, as transporters or cellular receptors. The systems we study are challenging, and we use multiple biophysical methods to address the questions we pose – this often leads us into methods development (both software and experimental) to allow us to obtain the answers we seek.
Projects focus on different biological systems ranging from bacterial pathogenesis systems to systems involved in human cell division. A common theme is how large, multiprotein, often membrane-crossing, complexes are assembled.
The studies of bacterial pathogenesis often examine large membrane-spanning complexes involved in bacterial protein/toxin secretion or bacterial movement. Research on human systems includes studies of serum-resident protein cascades involved in immune responses and coagulation, how centrosomes assemble during mitosis and how a variety of integral membrane proteins function in protein and membrane maturation, as transporters or cellular receptors. The systems we study are challenging, and we use multiple biophysical methods to address the questions we pose – this often leads us into methods development (both software and experimental) to allow us to obtain the answers we seek.
Research Interests
Papers共 445 篇Author StatisticsCo-AuthorSimilar Experts
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Nature Microbiologyno. 4 (2024): 1-14
P Aiden McCormick, Marie O'Grady,Cillian F De Gascun,John S Lambert,Orla Crosbie,Susan McKiernan, Maeve Skelly,Paul Holder,Garry Courtney,Brian Hennessy, Kevin Walsh, Roisin Twohig,
Irish journal of medical scienceno. 3 (2024): 1257-1260
Nature Microbiologyno. 5 (2024): 1-11
Nature Communicationsno. 1 (2023): 1-16
biorxiv(2023)
Ben C. Berks,Frédéric Lauber,Justin C. Deme,Xiaolong Liu, Andreas Kjær, Helen Miller,Felicity Alcock,Susan M. Lea
Research Square (Research Square) (2023)
mBio (2023)
Structure (London, England : 1993)no. 9 (2023): 1121-1131.e6
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