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The human body is constantly facing a barrage of insults from environmental or microbial challenges and yet, for the most part, we are unaware of these, because the immune cells in our body recognise and communicate these external challenges to the inside of the cell, resulting in appropriate behavioural changes of the cell to effectively eradicate the insult. But occasionally, this very effective, defence mechanism breaks down due to age-related weaknesses or ill-health. Such a breakdown in communication within the cell is highly dangerous and can result in diseases such as cancer, inflammation or autoimmune disorders. Therefore, understanding the players in the cell that facilitate and maintain normal communication networks, will provide us with a better understanding of how to tackle the problem when things go wrong.
Our research is focused on understanding what networks operate inside the cell to communicate changes in the external environment to the inside of the cell, and which protein components act as checkpoints to control the duration and amplitude of these communication circuits. In the long-term, these studies may help to identify potential drug targets that could be used to eradicate or curtail rogue cells in disease.
Our research is focused on understanding what networks operate inside the cell to communicate changes in the external environment to the inside of the cell, and which protein components act as checkpoints to control the duration and amplitude of these communication circuits. In the long-term, these studies may help to identify potential drug targets that could be used to eradicate or curtail rogue cells in disease.
研究兴趣
论文共 112 篇作者统计合作学者相似作者
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Annastazia E. Learoyd, Lauren Arnold,Fiona Reid,Nicholas Beckley-Hoelscher,Alina Casian,Shirish Sangle,Neil Morton,Louise Nel,Angela Cape,Susan John,Sangmi Kim, Dharshene Shivapatham,
Trialsno. 1 (2023): 1-14
Victoria Campbell,Charlotte Flanagan,Isabella Tosi,Christine Jones,Sean Whittaker,Susan John,Tracey Mitchell
BRITISH JOURNAL OF DERMATOLOGYno. 1 (2023): E12-E12
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Victoria Campbell,Charlotte E. Flanagan,Isabella Tosi,Christine L. Jones, Sean Whittaker,Susan John, Tracey Mitchell
British Journal of Dermatologyno. 1 (2023): e12-e12
Phillip M. Brailey,Lauren Evans,Juan Carlos López-Rodríguez, Anthony Sinadinos, Victoria Tyrrel,Gavin Kelly,Valerie O’Donnell,Peter Ghazal,Susan John,Patricia Barral
Leigh Anna Stubbs, Cynthia K Saliba,Erica K Schallert,Susan D John, Sutapa Khatua,Kristen G Valencia Deray,Alexandra M Stevens, Mary Esther M Rocha
Sangmi Kim,Lena Boehme, Louise Nel,Alina Casian, Shirish Sangle,Estefania Nova-Lamperti,Vlad Seitan,Jo Spencer,Paul Lavender,David P D'Cruz,Susan John
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