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Career Trajectory
Bio
Susan Taylor began her career in science when she chose chemistry as her major at the Univeristy of Wisconsin, which was a bold move for a woman in 1960. During college she was determined to go to medical school, but that all changed when she met her future husband, Palmer Taylor, who was finishing his Ph.D. at the University of Wisconsin and on his way to the National Institutes of Health for post-grad work. In a history changing moment, Taylor applied to graduate school at nearby Johns Hopkins University. After her first year at Hopkins, Taylor and Palmer were married.
When Palmer was invited to join a new molecular pharmacology program in Cambridge, England, Taylor landed a fellowship at the prestigious Medical Research Council Laboratory of Molecular Biology where her love of proteins began to blossom as she worked alongside Brian Hartley.
In 1970, Taylor's fellowship at MRC ended and she accepted a fellowship with Nathan Kaplan at UC San Diego where Palmer would be as well. Not long after she began her residency at UC San Diego, she secured a faculty position in the chemistry department.
Since then Taylor has made great leaps forward in elucidating the structure, dynamics, and localization of protein kinase A (PKA). PKA is one of the cell's most important signaling molecules. It helps regulate memory, development, cell growth and cell death. Defects in PKA are associated with immune disorders and many diseases such as cancer and cardiac disorders. In 1991 Taylor and her lab solved the crystal structure of PKA's catalytic subunit which is conserved throught the kinase family. However, there was still much to be discovered and in 2005 Taylor and her colleagues were able to explain how PKA's regulatory subunit inhibits the catalytic subunit in the absence of cAMP. This discovery lead to the full understanding of how PKA works.
Research Interests
Papers共 771 篇Author StatisticsCo-AuthorSimilar Experts
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CELL REPORTSno. 4 (2024): 114011-114011
Chiara R. Trilling,Jui-Hung Weng,Pallavi Kaila Sharma, Viktoria Nolte,Jian Wu,Wen Ma,Daniela Boassa,Susan S. Taylor,Friedrich W. Herberg
Jui-Hung Weng, Chiara R. Trilling,Pallavi Kaila Sharma, Eliza Stoermer, Jian Wu,Friedrich W. Herberg,Susan S. Taylor
JOURNAL OF MOLECULAR BIOLOGYno. 6 (2024)
Jui-Hung Weng, Chiara R Trilling,Pallavi Kaila Sharma,Eliza Störmer,Jian Wu,Friedrich W Herberg,Susan S Taylor
Journal of molecular biologyno. 6 (2024): 168485-168485
ELIFE (2024)
Philosophical transactions. Series A, Mathematical, physical, and engineering sciencesno. 2273 (2024): 20230195-20230195
Jian Wu, Nisha A Jonniya,Sophia P Hirakis,Cristina Olivieri,Gianluigi Veglia,Alexandr P Kornev,Susan S Taylor
bioRxiv : the preprint server for biology (2023)
Matrix Biology (2023): 8-22
Julia C. Hardy, Emily H. Pool,Jessica G.H. Bruystens,Xin Zhou, Qingrong Li, Daojia R. Zhou, Max Palay, Gerald Tan, Lisa Chen, Jaclyn L.C. Choi,Ha Neul Lee,Stefan Strack,
Molecular Cellno. 8 (2023): 1570-1584.e7
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